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Antimicrobial Agents and Chemotherapy, October 2002, p. 3331-3333, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3331-3333.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Effects of Clarithromycin and Amoxicillin on Gastric Emptying in Rats

Hiromi Endo,1* Hideo Yoshida,1 Yoshiro Kohno,1 and Tetsuya Suga2

Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd., Saitama-shi, Saitama 330-8530,1 Department of Clinical and Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan2

Received 31 October 2001/ Returned for modification 26 April 2002/ Accepted 1 July 2002

The effects of oral administration of clarithromycin (CLR), amoxicillin (AMX), and lansoprazole (LPZ) on gastric emptying in rats were investigated by a glass powder method and a phenol red method. By both test methods, no significant effects on gastric emptying were observed when CLR, AMX, or LPZ was administered alone or when the three drugs were administered concomitantly. The levels of gastrointestinal absorption of [14C]CLR and [14C]AMX were measured. Four hours after injection of [14C]CLR or [14C]AMX into the stomach and duodenum loops of rats, 86.63 and 1.27% of the original amount of [14C]CLR administered were recovered in the contents of the stomach and duodenum loops, respectively, and 80.01 and 55.88% of the original amount of [14C]AMX administered were recovered in the contents of the stomach and duodenum loops, respectively.

* Corresponding author. Mailing address: Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd., 403, Yoshino-cho 1-chome, Saitama-shi, Saitama 330-8530, Japan. Phone: 81 48 669 3036. Fax: 81 48 652 7254. E-mail: hiromi.endou{at}po.rd.taisho.co.jp.

Antimicrobial Agents and Chemotherapy, October 2002, p. 3331-3333, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3331-3333.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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