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Antimicrobial Agents and Chemotherapy, October 2002, p. 3334-3336, Vol. 46, No. 10
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.10.3334-3336.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Gene Dosage and Linezolid Resistance in Enterococcus faecium and Enterococcus faecalis

Research and Medical Services, Department of Veterans Affairs Medical Center and Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio

Received 15 March 2002/ Returned for modification 30 May 2002/ Accepted 18 July 2002

Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. We analyzed nine clinical isolates of linezolid-resistant enterococci and showed a clear association between the number of 23S rRNA genes containing this mutation and the level of linezolid resistance expressed.

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