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Antimicrobial Agents and Chemotherapy, November 2002, p. 3617-3620, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3617-3620.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Propranolol Inhibits Hyphal Development in Candida albicans

Carol A. Baker,1 Kevin Desrosiers,2 and Joseph W. Dolan3*

Department of Microbiology & Immunology,1 Department of Stomatology, Medical University of South Carolina, Charleston, South Carolina 29425,3 Department of Biology, Northeastern University, Boston, Massachusetts 021152

Received 28 February 2002/ Returned for modification 11 March 2002/ Accepted 15 August 2002

Propranolol was used to investigate the role of phosphatidic acid (PA) and diacylglycerol in the dimorphic transition in Candida albicans. Propranolol was able to inhibit the appearance of germ tubes without decreasing growth rate. Data suggest that inhibition of morphogenesis may be due to binding by propranolol of PA derived from PLD1 hydrolysis of phosphatidylcholine.

* Corresponding author. Mailing address: Department of Stomatology, Medical University of South Carolina, 173 Ashley Ave., P.O. Box 250504, Charleston, SC 29425. Phone: (843) 792-1904. Fax: (843) 792-2464. E-mail: dolanjw{at}musc.edu.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3617-3620, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3617-3620.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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