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Antimicrobial Agents and Chemotherapy, November 2002, p. 3627-3629, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3627-3629.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

TEM-103/IRT-28 ß-Lactamase, a New TEM Variant Produced by Escherichia coli BM4511

Rodrigo Alonso, Guy Gerbaud, Marc Galimand, and Patrice Courvalin*

Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France

Received 1 March 2002/ Returned for modification 4 June 2002/ Accepted 12 August 2002

Clinical isolate Escherichia coli BM4511 was resistant to broad-spectrum penicillins in the presence or in the absence of ß-lactamase inhibitors but remained susceptible to cephalosporins. Resistance was due to production of a new TEM-type ß-lactamase, designated TEM-103/IRT-28, characterized by the Arg275Leu substitution and encoded by the ca. 62-kb pIP845 conjugative plasmid of the IncI1 incompatibility group.

* Corresponding author. Mailing address: Unité des Agents Antibactériens, Institut Pasteur, 25 rue Dr. Roux, 75724 Paris Cedex 15, France. Phone: (33) 1 45 68 83 20. Fax: (33) 1 45 68 83 19. E-mail: pcourval{at}pasteur.fr.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3627-3629, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3627-3629.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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