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Antimicrobial Agents and Chemotherapy, November 2002, p. 3630-3633, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3630-3633.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics and Pharmacodynamics of Gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Granulocyte-Rich Exudate

Andrej Trampuz,1 Gerd Laifer,1 Markus Wenk,2 Zarko Rajacic,1 and Werner Zimmerli3*

Division of Infectious Diseases,1 Division of Clinical Pharmacology, Departments of Internal Medicine and Research, University Hospitals, Basel,2 University Medical Clinic, Liestal, Switzerland3

Received 16 October 2001/ Returned for modification 17 February 2002/ Accepted 3 August 2002

The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo.

* Corresponding author. Mailing address: University Medical Clinic, Rheinstrasse 26, CH-4410 Liestal, Switzerland. Phone: 41 61 925 2525. Fax: 41 61 925 2804. E-mail: werner.zimmerli{at}ksli.ch.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3630-3633, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3630-3633.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Stein, G. E., Schooley, S., Tyrrell, K. L., Citron, D. M., Goldstein, E. J. C. (2003). Bactericidal Activities of Methoxyfluoroquinolones Gatifloxacin and Moxifloxacin against Aerobic and Anaerobic Respiratory Pathogens in Serum. Antimicrob. Agents Chemother. 47: 1308-1312 [Abstract] [Full Text]  


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