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Antimicrobial Agents and Chemotherapy, November 2002, p. 3637-3640, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3637-3640.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Erythromycin Resistance in Borrelia burgdorferi

Darya Terekhova,1 Marina L. Sartakova,1 Gary P. Wormser,2 Ira Schwartz,1 and Felipe C. Cabello1*

Departments of Microbiology and Immunology,1 Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York 105952

Received 3 January 2002/ Returned for modification 1 May 2002/ Accepted 25 July 2002

Susceptibility testing of laboratory strains and clinical isolates of Borrelia burgdorferi indicates that resistance to erythromycin is present in them. Evaluation of the MICs, minimal bactericidal concentrations, and kinetics of bacterial killing of erythromycin suggests that this resistance is increased by preexposure to the antibiotic, is dependent on inoculum size, and may be the result of selection of subpopulations of bacterial cells with increased resistance.

* Corresponding author. Mailing address: Departments of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595. Phone: (914) 594-4182. Fax: (914) 594-4176. E-mail: cabello{at}nymc.edu.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3637-3640, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3637-3640.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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