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Antimicrobial Agents and Chemotherapy, November 2002, p. 3650-3653, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3650-3653.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Antibacterial Activities of Phloxine B and Other Halogenated Fluoresceins against Methicillin-Resistant Staphylococcus aureus

Avraham Rasooly1 and Adrian Weisz2*

Office of Plant and Dairy Foods and Beverages, U.S. Food and Drug Administration, College Park, Maryland 20740,1 Office of Cosmetics and Colors, U.S. Food and Drug Administration, Washington, D.C. 202042

Received 11 February 2002/ Returned for modification 26 June 2002/ Accepted 25 July 2002

Fluorescein dyes in which the benzoic acid moiety has been tetrachlorinated (50 to 100 µg/ml) inhibit in vitro Staphylococcus aureus growth (MIC, 25 µg/ml). Specifically, under standard room illumination, phloxine B at a concentration of 100 µg/ml killed 99% of the cultures (mid-log phase). It also reduced S. aureus CFU by 104. Structure-activity analysis revealed that the activity against S. aureus increases with the increase in the number of the substituting halogens in the hydroxyxanthene moiety.

* Corresponding author. Mailing address: Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-126, 200 C St., S.W., Washington, DC 20204. Phone: (202) 205-4718. Fax: (202) 205-5098. E-mail: aweisz{at}cfsan.fda.gov.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3650-3653, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3650-3653.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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