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Antimicrobial Agents and Chemotherapy, November 2002, p. 3654-3656, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3654-3656.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Pitfalls in Cefepime Titration from Human Plasma: Plasma- and Temperature-Related Drug Degradation In Vitro

Denis Bugnon, Eric Giannoni, Paul Majcherczyk, Michel P. Glauser, and Philippe Moreillon*

Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland

Received 11 October 2001/ Returned for modification 5 May 2002/ Accepted 5 August 2002

While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37°C but not at 4°C. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo.

* Corresponding author. Mailing address: Division of Infectious Diseases, CHUV-BH19, 1011 Lausanne, Switzerland. Phone: 41-21-314.10.26. Fax: 41-21-314.10.36. E-mail: Philippe.Moreillon{at}chuv.hospvd.ch.

Antimicrobial Agents and Chemotherapy, November 2002, p. 3654-3656, Vol. 46, No. 11
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.11.3654-3656.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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  • Baririan, N., Chanteux, H., Viaene, E., Servais, H., Tulkens, P. M. (2003). Stability and compatibility study of cefepime in comparison with ceftazidime for potential administration by continuous infusion under conditions pertinent to ambulatory treatment of cystic fibrosis patients and to administration in intensive care units. J Antimicrob Chemother 51: 651-658 [Abstract] [Full Text]  


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