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Antimicrobial Agents and Chemotherapy, December 2002, p. 3987-3990, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.3987-3990.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Erythromycin-Resistant Pharyngeal Isolates of Streptococcus pyogenes Recovered in Italy

Giordano Dicuonzo,1,2 Ersilia Fiscarelli,3 Giovanni Gherardi,1 Giulia Lorino,4 Fabrizio Battistoni,1 Simona Landi,3 Marina De Cesaris,1 Tommasangelo Petitti,2 and Bernard Beall5*

Department of Laboratory Medicine,1 Hospital Infection Control Program, Università Campus Bio-Medico,2 Servizio di Medicina di Laboratorio, Ospedale Bambino Gesù,3 Istituto di Microbiologia, Università La Sapienza, Rome, Italy,4 WHO Collaborating Center for Streptococcal Research, Respiratory Diseases Branch, Centers For Disease Control and Prevention, Atlanta, Georgia 303335

Received 2 January 2002/ Returned for modification 11 April 2002/ Accepted 10 September 2002

Three classes of macrolide resistance phenotypes and three different erythromycin resistance determinants were found among 127 erythromycin-resistant group A streptococcal (GAS) isolates recovered from 355 (35.8%) pediatric pharyngitis patients in Rome, Italy. According to emm and sof sequence typing results, erythromycin-resistant isolates comprised 11 different clonal types. Remarkably, 126 of the 127 macrolide-resistant isolates were serum opacity factor (sof) gene positive. These data suggest a strong association between macrolide resistance and the presence of sof among GAS isolates recovered from Italian pediatric pharyngitis patients.


* Corresponding author. Mailing address: WHO Collaborating Center for Streptococcal Research, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333. Phone: (404) 639-1237. Fax: (404) 639-3123. E-mail: bbeall{at}cdc.gov.


Antimicrobial Agents and Chemotherapy, December 2002, p. 3987-3990, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.3987-3990.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.




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