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Antimicrobial Agents and Chemotherapy, December 2002, p. 3987-3990, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.3987-3990.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Erythromycin-Resistant Pharyngeal Isolates of Streptococcus pyogenes Recovered in Italy

Department of Laboratory Medicine,¹ Hospital Infection Control Program, Università Campus Bio-Medico,² Servizio di Medicina di Laboratorio, Ospedale Bambino Gesù,³ Istituto di Microbiologia, Università La Sapienza, Rome, Italy,⁴ WHO Collaborating Center for Streptococcal Research, Respiratory Diseases Branch, Centers For Disease Control and Prevention, Atlanta, Georgia 30333⁵

Received 2 January 2002/ Returned for modification 11 April 2002/ Accepted 10 September 2002

Three classes of macrolide resistance phenotypes and three different erythromycin resistance determinants were found among 127 erythromycin-resistant group A streptococcal (GAS) isolates recovered from 355 (35.8%) pediatric pharyngitis patients in Rome, Italy. According to emm and sof sequence typing results, erythromycin-resistant isolates comprised 11 different clonal types. Remarkably, 126 of the 127 macrolide-resistant isolates were serum opacity factor (sof) gene positive. These data suggest a strong association between macrolide resistance and the presence of sof among GAS isolates recovered from Italian pediatric pharyngitis patients.

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