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Antimicrobial Agents and Chemotherapy, December 2002, p. 4000-4003, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4000-4003.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Phenotypic and Genotypic Analysis of Biologically Cloned Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Zidovudine and Lamivudine

Thomas C. Stoeckli,^1, Samantha MaWhinney,² Jonathan Uy,^1, Chengying Duan,¹ Jing Lu,¹ David Shugarts,¹ and Daniel R. Kuritzkes^1*

Division of Infectious Diseases,¹ Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262²

Received 25 February 2002/ Returned for modification 30 May 2002/ Accepted 20 August 2002

Mutations at reverse transcriptase codons 44, 118, 207, and 208 were significantly correlated with reduced zidovudine susceptibility in biologically cloned human immunodeficiency virus type 1 (HIV-1) isolates. Sequences from the Stanford HIV RT and Protease Sequence Database showed that these mutations were more common in HIV-1 isolates from patients treated with zidovudine and lamivudine than in patients not treated with these drugs.

Present address: Buergerspital, 4500 Solothurn, Switzerland.

Present address: Division of Infectious Diseases, University of Illinois-Chicago, Chicago, IL.

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