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Antimicrobial Agents and Chemotherapy, December 2002, p. 4013-4015, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4013-4015.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Uptake and Intracellular Activity of Linezolid in Human Phagocytes and Nonphagocytic Cells

Álvaro Pascual,* Sofía Ballesta, Isabel García, and Evelio J. Perea

Department of Microbiology, School of Medicine, University of Seville, Seville, Spain

Received 13 November 2001/ Returned for modification 19 June 2002/ Accepted 12 August 2002

The intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells (McCoy) were evaluated. Linezolid reached intracellular concentrations slightly greater than extracellular ones in both types of cell. The uptake was rapid and not saturable and was affected by environmental temperature and cell viability. Linezolid showed slight intracellular activity against Staphylococcus epidermidis at high extracellular concentrations.

* Corresponding author. Mailing address: Departament of Microbiology, School of Medicine, University of Seville, Avda. Sánchez Pizjuán s/n, 41009-Seville, Spain. Phone: 34.5.55008287. Fax: 34.5.4377413. E-mail: atomas{at}us.es.

Antimicrobial Agents and Chemotherapy, December 2002, p. 4013-4015, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4013-4015.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Condos, R., Hadgiangelis, N., Leibert, E., Jacquette, G., Harkin, T., Rom, W. N. (2008). Case Series Report of a Linezolid-Containing Regimen for Extensively Drug-Resistant Tuberculosis. Chest 134: 187-192 [Abstract] [Full Text]  


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