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Antimicrobial Agents and Chemotherapy, December 2002, p. 4016-4018, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4016-4018.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

New Automated Method for Determining Postantifungal Effect of Amphotericin B against Candida Species: Effects of Concentration, Exposure Time, and Area under the Curve

Erja Chryssanthou,1* Otto Cars,2 and Jan Sjölin2

Department of Clinical Microbiology, Karolinska Hospital, Stockholm,1 Antibiotic Research Unit, Section of Infectious Diseases, Department of Medical Sciences, University Hospital, Uppsala, Sweden2

Received 9 October 2001/ Returned for modification 25 March 2002/ Accepted 28 August 2002

The postantifungal effect (PAFE) of amphotericin B was determined with a BacT/Alert automated system, which is based on the colorimetric detection of CO2. The levels of accuracy and precision of the automated method were high. Longer PAFEs were obtained for Candida albicans (P < 0.001), C. glabrata (P < 0.01), and C. krusei (P < 0.01) at increasing amphotericin B concentrations and exposure times.

* Corresponding author. Mailing address: Department of Clinical Microbiology, L202 Karolinska Hospital, S-171 76 Stockholm, Sweden. Phone: 46 8 517 73566. Fax: 46 8 308099. E-mail: Erja.Chryssanthou{at}ks.se.

Antimicrobial Agents and Chemotherapy, December 2002, p. 4016-4018, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4016-4018.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chryssanthou, E., Loebig, A., Sjolin, J. (2008). Post-antifungal effect of amphotericin B and voriconazole against germinated Aspergillus fumigatus conidia. J Antimicrob Chemother 61: 1309-1311 [Abstract] [Full Text]  
  • Di Bonaventura, G., Spedicato, I., Picciani, C., D'Antonio, D., Piccolomini, R. (2004). In Vitro Pharmacodynamic Characteristics of Amphotericin B, Caspofungin, Fluconazole, and Voriconazole against Bloodstream Isolates of Infrequent Candida Species from Patients with Hematologic Malignancies. Antimicrob. Agents Chemother. 48: 4453-4456 [Abstract] [Full Text]  
  • Chryssanthou, E., Sjolin, J. (2004). Post-antifungal effect of amphotericin B and voriconazole against Aspergillus fumigatus analysed by an automated method based on fungal CO2 production: dependence on exposure time and drug concentration. J Antimicrob Chemother 54: 940-943 [Abstract] [Full Text]  


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