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Antimicrobial Agents and Chemotherapy, December 2002, p. 4022-4025, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4022-4025.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Postantibiotic Effect and Delay of Regrowth in Strains Carrying Mutations That Save Proteins or RNA

Marzia Dolcino, Alberto Zoratti, Eugenio A. Debbia,* Gian Carlo Schito, and Anna Marchese

Institute of Microbiology C.A. Romanzi, University of Genoa, 16132 Genoa, Italy

Received 13 July 2001/ Returned for modification 18 March 2002/ Accepted 29 August 2002

The postantibiotic effect (PAE) values found for proteinase-defective (Lon-) Escherichia coli and RNase-defective E. coli exposed to antibiotics were reduced (31 to 60% and 35 to 50%, respectively) in comparison with the control (AB1157), and in the recA13 mutant these values were about 0.4 h with all drugs. Nalidixic acid, under anaerobic conditions, induced no PAE (0 to 0.1 h) in AB1157. A delay in regrowth (0.2 to 0.26 h) was noted with dnaA46(Ts), gyrA43(Ts), and gyrB41(Ts) mutants cultured for 2 h at 43°C. These findings suggest that when proteins and RNA are saved, the cell rapidly resumes the original growth rate.

* Corresponding author. Mailing address: Institute of Microbiology C.A. Romanzi, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy. Phone: 39-010-3537646. Fax: 39-010-504837. E-mail: eugenio.debbia{at}unige.it.

Antimicrobial Agents and Chemotherapy, December 2002, p. 4022-4025, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4022-4025.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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Copyright © 2002 by the American Society for Microbiology. All rights reserved.