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Antimicrobial Agents and Chemotherapy, December 2002, p. 4026-4028, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4026-4028.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Novel Variant (bla_VIM-4) of the Metallo-ß-Lactamase Gene bla_VIM-1 in a Clinical Strain of Pseudomonas aeruginosa

Department of Medical Microbiology, University of Thessaly, Larissa,¹ Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki,² Department of Microbiology, Medical School, University of Athens, Athens, Greece³

Received 11 April 2002/ Returned for modification 16 May 2002/ Accepted 11 September 2002

A Pseudomonas aeruginosa isolate highly resistant to carbapenems was collected from a patient with postsurgical cerebrospinal infection in Greece. The isolate carried a class 1 integron that contained as a sole cassette the gene bla_VIM-4, a novel variant of bla_VIM-1, with one nucleotide difference resulting in a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme. This is the first detection of a VIM-1 variant after its appearance in Italy.

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