AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lartigue, M. F.
Right arrow Articles by Nicolas-Chanoine, M.-H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lartigue, M. F.
Right arrow Articles by Nicolas-Chanoine, M.-H.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, December 2002, p. 4035-4037, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4035-4037.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Promoters P3, Pa/Pb, P4, and P5 Upstream from blaTEM Genes and Their Relationship to ß-Lactam Resistance

Marie Frédérique Lartigue,1,2 Véronique Leflon-Guibout,1,2 Laurent Poirel,3,4 Patrice Nordmann,3,4 and Marie-Hélène Nicolas-Chanoine1,2*

Service de Microbiologie-Hygiène, Hôpital Ambroise Paré Assistance Publique-Hôpitaux de Paris, Boulogne,1 Faculté Paris Ile-de-France Ouest, Université Versailles Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines,2 Service de Bactériologie-Virologie, Hôpital Bicêtre,3 Assistance Publique-Hôpitaux de Paris,4 Le Kremlin Bicêtre, and Faculté de Médecine Université Paris XI, Paris, France5

Received 23 May 2002/ Returned for modification 24 July 2002/ Accepted 25 August 2002

Using an isogenic system, we have determined the impact that the four promoters known to control blaTEM gene expression have on ß-lactamase activity. For both TEM-1 and TEM-30, this activity gradually increased in relation to the presence of promoters P3, Pa/Pb, and P4 upstream of the corresponding gene. Promoter P5, only found upstream of the blaTEM-1B gene, was related to the highest expression of this gene.

* Corresponding author. Mailing address: Hôpital Ambroise Paré, Service de Microbiologie-Hygiène, 9 avenue Charles de Gaulle, 92100 Boulogne Billancourt, France. Phone: 33-1-49-09-55-40. Fax: 33-1-49-09-59-21. E-mail: marie-helene.nicolas-chanoine{at}apr.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, December 2002, p. 4035-4037, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4035-4037.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2002 by the American Society for Microbiology. All rights reserved.