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Antimicrobial Agents and Chemotherapy, December 2002, p. 4038-4040, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4038-4040.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Chromosome-Encoded Ambler Class A ß-Lactamase of Kluyvera georgiana, a Probable Progenitor of a Subgroup of CTX-M Extended-Spectrum ß-Lactamases

Laurent Poirel,1 Peter Kämpfer,2 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France,1 Institut für Angewandte Mikrobiologie, Justus-Liebig-Universität Giessen, 35392 Giessen, Germany2

Received 22 April 2002/ Returned for modification 30 May 2002/ Accepted 10 September 2002

A chromosome-encoded ß-lactamase gene, cloned and expressed in Escherichia coli from Kluyvera georgiana reference strain CUETM 4246-74 (DSM 9408), encoded the extended-spectrum ß-lactamase KLUG-1, which shared 99% amino acid identity with the plasmid-mediated ß-lactamase CTX-M-8. This work provides further evidence that Kluyvera spp. may be the progenitor(s) of CTX-M-type ß-lactamases.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, December 2002, p. 4038-4040, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4038-4040.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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