This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Poirel, L.
Right arrow Articles by Nordmann, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Poirel, L.
Right arrow Articles by Nordmann, P.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, December 2002, p. 4038-4040, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4038-4040.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Chromosome-Encoded Ambler Class A ß-Lactamase of Kluyvera georgiana, a Probable Progenitor of a Subgroup of CTX-M Extended-Spectrum ß-Lactamases

Laurent Poirel,1 Peter Kämpfer,2 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France,1 Institut für Angewandte Mikrobiologie, Justus-Liebig-Universität Giessen, 35392 Giessen, Germany2

Received 22 April 2002/ Returned for modification 30 May 2002/ Accepted 10 September 2002

A chromosome-encoded ß-lactamase gene, cloned and expressed in Escherichia coli from Kluyvera georgiana reference strain CUETM 4246-74 (DSM 9408), encoded the extended-spectrum ß-lactamase KLUG-1, which shared 99% amino acid identity with the plasmid-mediated ß-lactamase CTX-M-8. This work provides further evidence that Kluyvera spp. may be the progenitor(s) of CTX-M-type ß-lactamases.


* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.


Antimicrobial Agents and Chemotherapy, December 2002, p. 4038-4040, Vol. 46, No. 12
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.12.4038-4040.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:

  • Fabre, L., Delaune, A., Espie, E., Nygard, K., Pardos, M., Polomack, L., Guesnier, F., Galimand, M., Lassen, J., Weill, F.-X. (2009). Chromosomal Integration of the Extended-Spectrum {beta}-Lactamase Gene blaCTX-M-15 in Salmonella enterica Serotype Concord Isolates from Internationally Adopted Children. Antimicrob. Agents Chemother. 53: 1808-1816 [Abstract] [Full Text]  
  • Navon-Venezia, S., Chmelnitsky, I., Leavitt, A., Carmeli, Y. (2008). Dissemination of the CTX-M-25 family {beta}-lactamases among Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae and identification of the novel enzyme CTX-M-41 in Proteus mirabilis in Israel. J Antimicrob Chemother 62: 289-295 [Abstract] [Full Text]  
  • Poirel, L., Figueiredo, S., Cattoir, V., Carattoli, A., Nordmann, P. (2008). Acinetobacter radioresistens as a Silent Source of Carbapenem Resistance for Acinetobacter spp.. Antimicrob. Agents Chemother. 52: 1252-1256 [Abstract] [Full Text]  
  • Golebiewski, M., Kern-Zdanowicz, I., Zienkiewicz, M., Adamczyk, M., Zylinska, J., Baraniak, A., Gniadkowski, M., Bardowski, J., Ceglowski, P. (2007). Complete Nucleotide Sequence of the pCTX-M3 Plasmid and Its Involvement in Spread of the Extended-Spectrum {beta}-Lactamase Gene blaCTX-M-3. Antimicrob. Agents Chemother. 51: 3789-3795 [Abstract] [Full Text]  
  • Naas, T., Oxacelay, C., Nordmann, P. (2007). Identification of CTX-M-Type Extended-Spectrum-{beta}-Lactamase Genes Using Real-Time PCR and Pyrosequencing. Antimicrob. Agents Chemother. 51: 223-230 [Abstract] [Full Text]  
  • Potz, N. A. C., Hope, R., Warner, M., Johnson, A. P., Livermore, D. M., on behalf of the London & South East ESBL Project, (2006). Prevalence and mechanisms of cephalosporin resistance in Enterobacteriaceae in London and South-East England. J Antimicrob Chemother 58: 320-326 [Abstract] [Full Text]  
  • Jacoby, G. A. (2006). {beta}-Lactamase Nomenclature.. Antimicrob. Agents Chemother. 50: 1123-1129 [Full Text]  
  • Lartigue, M.-F., Poirel, L., Aubert, D., Nordmann, P. (2006). In Vitro Analysis of ISEcp1B-Mediated Mobilization of Naturally Occurring {beta}-Lactamase Gene blaCTX-M of Kluyvera ascorbata.. Antimicrob. Agents Chemother. 50: 1282-1286 [Abstract] [Full Text]  
  • Eisner, A., Fagan, E. J., Feierl, G., Kessler, H. H., Marth, E., Livermore, D. M., Woodford, N. (2006). Emergence of Enterobacteriaceae Isolates Producing CTX-M Extended-Spectrum {beta}-Lactamase in Austria. Antimicrob. Agents Chemother. 50: 785-787 [Abstract] [Full Text]  
  • Shibata, N., Kurokawa, H., Doi, Y., Yagi, T., Yamane, K., Wachino, J.-i., Suzuki, S., Kimura, K., Ishikawa, S., Kato, H., Ozawa, Y., Shibayama, K., Kai, K., Konda, T., Arakawa, Y. (2006). PCR Classification of CTX-M-Type {beta}-Lactamase Genes Identified in Clinically Isolated Gram-Negative Bacilli in Japan. Antimicrob. Agents Chemother. 50: 791-795 [Abstract] [Full Text]  
  • Eckert, C., Gautier, V., Arlet, G. (2006). DNA sequence analysis of the genetic environment of various blaCTX-M genes. J Antimicrob Chemother 57: 14-23 [Abstract] [Full Text]  
  • Paterson, D. L., Bonomo, R. A. (2005). Extended-Spectrum {beta}-Lactamases: a Clinical Update. Clin. Microbiol. Rev. 18: 657-686 [Abstract] [Full Text]  
  • Poirel, L., Rodriguez-Martinez, J.-M., Mammeri, H., Liard, A., Nordmann, P. (2005). Origin of Plasmid-Mediated Quinolone Resistance Determinant QnrA. Antimicrob. Agents Chemother. 49: 3523-3525 [Abstract] [Full Text]  
  • Pitout, J. D. D., Nordmann, P., Laupland, K. B., Poirel, L. (2005). Emergence of Enterobacteriaceae producing extended-spectrum {beta}-lactamases (ESBLs) in the community. J Antimicrob Chemother 56: 52-59 [Abstract] [Full Text]  
  • Vignoli, R., Varela, G., Mota, M. I., Cordeiro, N. F., Power, P., Ingold, E., Gadea, P., Sirok, A., Schelotto, F., Ayala, J. A., Gutkind, G. (2005). Enteropathogenic Escherichia coli Strains Carrying Genes Encoding the PER-2 and TEM-116 Extended-Spectrum {beta}-Lactamases Isolated from Children with Diarrhea in Uruguay. J. Clin. Microbiol. 43: 2940-2943 [Abstract] [Full Text]  
  • Poirel, L., Cabanne, L., Vahaboglu, H., Nordmann, P. (2005). Genetic Environment and Expression of the Extended-Spectrum {beta}-Lactamase blaPER-1 Gene in Gram-Negative Bacteria. Antimicrob. Agents Chemother. 49: 1708-1713 [Abstract] [Full Text]  
  • Olson, A. B., Silverman, M., Boyd, D. A., McGeer, A., Willey, B. M., Pong-Porter, V., Daneman, N., Mulvey, M. R. (2005). Identification of a Progenitor of the CTX-M-9 Group of Extended-Spectrum {beta}-Lactamases from Kluyvera georgiana Isolated in Guyana. Antimicrob. Agents Chemother. 49: 2112-2115 [Abstract] [Full Text]  
  • Oliver, A., Coque, T. M., Alonso, D., Valverde, A., Baquero, F., Canton, R. (2005). CTX-M-10 Linked to a Phage-Related Element Is Widely Disseminated among Enterobacteriaceae in a Spanish Hospital. Antimicrob. Agents Chemother. 49: 1567-1571 [Abstract] [Full Text]  
  • Bouallegue-Godet, O., Salem, Y. B., Fabre, L., Demartin, M., Grimont, P. A. D., Mzoughi, R., Weill, F.-X. (2005). Nosocomial Outbreak Caused by Salmonella enterica Serotype Livingstone Producing CTX-M-27 Extended-Spectrum {beta}-Lactamase in a Neonatal Unit in Sousse, Tunisia. J. Clin. Microbiol. 43: 1037-1044 [Abstract] [Full Text]  
  • Ho, P. L., Shek, R. H. L., Chow, K. H., Duan, R. S., Mak, G. C., Lai, E. L., Yam, W. C., Tsang, K. W., Lai, W. M. (2005). Detection and characterization of extended-spectrum {beta}-lactamases among bloodstream isolates of Enterobacter spp. in Hong Kong, 2000-2002. J Antimicrob Chemother 55: 326-332 [Abstract] [Full Text]  
  • Munday, C. J., Boyd, D. A., Brenwald, N., Miller, M., Andrews, J. M., Wise, R., Mulvey, M. R., Hawkey, P. M. (2004). Molecular and Kinetic Comparison of the Novel Extended-Spectrum {beta}-Lactamases CTX-M-25 and CTX-M-26. Antimicrob. Agents Chemother. 48: 4829-4834 [Abstract] [Full Text]  
  • Rodriguez, M. M., Power, P., Radice, M., Vay, C., Famiglietti, A., Galleni, M., Ayala, J. A., Gutkind, G. (2004). Chromosome-Encoded CTX-M-3 from Kluyvera ascorbata: a Possible Origin of Plasmid-Borne CTX-M-1-Derived Cefotaximases. Antimicrob. Agents Chemother. 48: 4895-4897 [Abstract] [Full Text]  
  • Pitout, J. D. D., Hossain, A., Hanson, N. D. (2004). Phenotypic and Molecular Detection of CTX-M-{beta}-Lactamases Produced by Escherichia coli and Klebsiella spp.. J. Clin. Microbiol. 42: 5715-5721 [Abstract] [Full Text]  
  • Decre, D., Burghoffer, B., Gautier, V., Petit, J.-C., Arlet, G. (2004). Outbreak of multi-resistant Klebsiella oxytoca involving strains with extended-spectrum {beta}-lactamases and strains with extended-spectrum activity of the chromosomal {beta}-lactamase. J Antimicrob Chemother 54: 881-888 [Abstract] [Full Text]  
  • Boyd, D. A., Tyler, S., Christianson, S., McGeer, A., Muller, M. P., Willey, B. M., Bryce, E., Gardam, M., Nordmann, P., Mulvey, M. R. (2004). Complete Nucleotide Sequence of a 92-Kilobase Plasmid Harboring the CTX-M-15 Extended-Spectrum Beta-Lactamase Involved in an Outbreak in Long-Term-Care Facilities in Toronto, Canada. Antimicrob. Agents Chemother. 48: 3758-3764 [Abstract] [Full Text]  
  • Woodford, N., Ward, M. E., Kaufmann, M. E., Turton, J., Fagan, E. J., James, D., Johnson, A. P., Pike, R., Warner, M., Cheasty, T., Pearson, A., Harry, S., Leach, J. B., Loughrey, A., Lowes, J. A., Warren, R. E., Livermore, D. M. (2004). Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum {beta}-lactamases in the UK. J Antimicrob Chemother 54: 735-743 [Abstract] [Full Text]  
  • Eckert, C., Gautier, V., Saladin-Allard, M., Hidri, N., Verdet, C., Ould-Hocine, Z., Barnaud, G., Delisle, F., Rossier, A., Lambert, T., Philippon, A., Arlet, G. (2004). Dissemination of CTX-M-Type {beta}-Lactamases among Clinical Isolates of Enterobacteriaceae in Paris, France. Antimicrob. Agents Chemother. 48: 1249-1255 [Abstract] [Full Text]  
  • Bonnet, R. (2004). Growing Group of Extended-Spectrum {beta}-Lactamases: the CTX-M Enzymes. Antimicrob. Agents Chemother. 48: 1-14 [Full Text]  
  • Edelstein, M., Pimkin, M., Palagin, I., Edelstein, I., Stratchounski, L. (2003). Prevalence and Molecular Epidemiology of CTX-M Extended-Spectrum {beta}-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in Russian Hospitals. Antimicrob. Agents Chemother. 47: 3724-3732 [Abstract] [Full Text]  
  • Paterson, D. L., Hujer, K. M., Hujer, A. M., Yeiser, B., Bonomo, M. D., Rice, L. B., Bonomo, R. A., the International Klebsiella Study Group,, (2003). Extended-Spectrum {beta}-Lactamases in Klebsiella pneumoniae Bloodstream Isolates from Seven Countries: Dominance and Widespread Prevalence of SHV- and CTX-M-Type {beta}-Lactamases. Antimicrob. Agents Chemother. 47: 3554-3560 [Abstract] [Full Text]  
  • Poirel, L., Decousser, J.-W., Nordmann, P. (2003). Insertion Sequence ISEcp1B Is Involved in Expression and Mobilization of a blaCTX-M {beta}-Lactamase Gene. Antimicrob. Agents Chemother. 47: 2938-2945 [Abstract] [Full Text]  
  • Pagani, L., Dell'Amico, E., Migliavacca, R., D'Andrea, M. M., Giacobone, E., Amicosante, G., Romero, E., Rossolini, G. M. (2003). Multiple CTX-M-Type Extended-Spectrum {beta}-Lactamases in Nosocomial Isolates of Enterobacteriaceae from a Hospital in Northern Italy. J. Clin. Microbiol. 41: 4264-4269 [Abstract] [Full Text]  
  • Mushtaq, S., Woodford, N., Potz, N., Livermore, D. M. (2003). Detection of CTX-M-15 extended-spectrum {beta}-lactamase in the United Kingdom. J Antimicrob Chemother 52: 528-529 [Full Text]  
  • Beauchef-Havard, A., Arlet, G., Gautier, V., Labia, R., Grimont, P., Philippon, A. (2003). Molecular and Biochemical Characterization of a Novel Class A {beta}-Lactamase (HER-1) from Escherichia hermannii. Antimicrob. Agents Chemother. 47: 2669-2673 [Abstract] [Full Text]