This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Darouiche, R. O.
Right arrow Articles by Reller, L. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Darouiche, R. O.
Right arrow Articles by Reller, L. B.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, February 2002, p. 543-545, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.543-545.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Antimicrobial Activity of Prosthetic Heart Valve Sewing Cuffs Coated With Minocycline and Rifampin

Rabih O. Darouiche,1* Vance G. Fowler, Jr.,2 Karim Adal,3 Marcia Kielhofner,4 David Mansouri,1 and L. Barth Reller2

Center for Prostheses Infection, Baylor College of Medicine and Veterans Affairs Medical Center,1 St. Luke's Episcopal Hospital, Houston, Texas 77030,4 Duke University Medical Center, Durham, North Carolina 27705,2 Cleveland Clinic Foundation, Cleveland, Ohio 441953

Received 8 February 2001/ Returned for modification 25 August 2001/ Accepted 4 November 2001

Prosthetic heart valve sewing cuffs coated with minocycline and rifampin exhibited in vitro zones of inhibition against all 52 tested clinical isolates responsible for prosthetic valve endocarditis. An in vitro elution study of these coated sewing cuffs demonstrated residual zones of inhibition against Staphylococcus epidermidis for at least 4 weeks.

* Corresponding author. Mailing address: Center for Prostheses Infection, Baylor College of Medicine, 1333 Moursund Ave., Suite A221, Houston, TX 77030. Phone: (713) 799-5088. Fax: (713) 799-5058. E-mail: rdarouiche{at}aol.com.

Antimicrobial Agents and Chemotherapy, February 2002, p. 543-545, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.543-545.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»