This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nagai, K.
Right arrow Articles by Urbaskova, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagai, K.
Right arrow Articles by Urbaskova, P.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, February 2002, p. 546-549, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.546-549.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Susceptibility to Telithromycin in 1,011 Streptococcus pyogenes Isolates from 10 Central and Eastern European Countries

Kensuke Nagai,1 Peter C. Appelbaum,1* Todd A. Davies,1 Linda M. Kelly,1 Dianne B. Hoellman,1 Arjana Tambic Andrasevic,2 Liga Drukalska,3 Waleria Hryniewicz,4 Michael R. Jacobs,5 Jana Kolman,6 Jolanta Miciuleviciene,7 Marina Pana,8 Lena Setchanova,9 Marianne Konkoly Thege,10 Helena Hupkova,11 Jan Trupl,12 and Pavla Urbaskova13

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania,1 University Hospital of Infectious Diseases, Zagreb, Croatia,2 Children's Hospital of Medical Academy of Latvia, Riga, Latvia,3 SeraVaccine Laboratory, Warsaw, Poland,4 Case Western Reserve University, Cleveland, Ohio,5 University of Ljubljana, Ljubljana, Slovenia,6 Kaunas Medical University Hospital, Kaunas, Lithuania,7 Institute Cantacuzino, Bucharest, Romania,8 Hospital of Infectious Diseases, Medical Academy, Sofia, Bulgaria,9 National Center for Epidemiology, Budapest, Hungary,10 St. CyrilMethod Hospital,11 National Cancer Institute, Bratislava Slovak Republic,12 National Antibiotic Reference Laboratory, Prague, Czech Republic,13

Received 24 August 2001/ Returned for modification 23 October 2001/ Accepted 6 November 2001

Among 1,011 recently isolated Streptococcus pyogenes isolates from 10 Central and Eastern European centers, the MICs at which 50% of isolates are inhibited (MIC50s) and the MIC90s were as follows: for telithromycin, 0.03 and 0.06 µg/ml, respectively; for erythromycin, azithromycin, and clarithromycin, 0.06 to 0.125 and 1 to 8 µg/ml, respectively; and for clindamycin, 0.125 and 0.125 µg/ml, respectively. Erythromycin resistance occurred in 12.3% of strains. Erm(A) [subclass erm(TR)] was most commonly encountered (60.5%), followed by mef(A) (23.4%) and erm(B) (14.5%). At <0.5 µg/ml, telithromycin was active against 98.5% of the strains tested.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, 500 University Dr., Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, February 2002, p. 546-549, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.546-549.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Richter, S. S., Heilmann, K. P., Dohrn, C. L., Beekmann, S. E., Riahi, F., Garcia-de-Lomas, J., Ferech, M., Goossens, H., Doern, G. V. (2008). Increasing telithromycin resistance among Streptococcus pyogenes in Europe. J Antimicrob Chemother 61: 603-611 [Abstract] [Full Text]  
  • Sidhu, A. B. S., Sun, Q., Nkrumah, L. J., Dunne, M. W., Sacchettini, J. C., Fidock, D. A. (2007). In Vitro Efficacy, Resistance Selection, and Structural Modeling Studies Implicate the Malarial Parasite Apicoplast as the Target of Azithromycin. J. Biol. Chem. 282: 2494-2504 [Abstract] [Full Text]  
  • Pankuch, G. A., Lin, G., Hoellman, D. B., Good, C. E., Jacobs, M. R., Appelbaum, P. C. (2006). Activity of Retapamulin against Streptococcus pyogenes and Staphylococcus aureus Evaluated by Agar Dilution, Microdilution, E-Test, and Disk Diffusion Methodologies.. Antimicrob. Agents Chemother. 50: 1727-1730 [Abstract] [Full Text]  
  • Silva-Costa, C., Ramirez, M., Melo-Cristino, J., the Portuguese Surveillance Group for the Study of, (2005). Rapid Inversion of the Prevalences of Macrolide Resistance Phenotypes Paralleled by a Diversification of T and emm Types among Streptococcus pyogenes in Portugal. Antimicrob. Agents Chemother. 49: 2109-2111 [Abstract] [Full Text]  
  • Szczypa, K., Sadowy, E., Izdebski, R., Hryniewicz, W. (2004). A rapid increase in macrolide resistance in Streptococcus pyogenes isolated in Poland during 1996-2002. J Antimicrob Chemother 54: 828-831 [Abstract] [Full Text]  
  • Uh, Y., Jang, I. H., Hwang, G. Y., Lee, M. K., Yoon, K. J., Kim, H. Y. (2004). Antimicrobial Susceptibility Patterns and Macrolide Resistance Genes of {beta}-Hemolytic Streptococci in Korea. Antimicrob. Agents Chemother. 48: 2716-2718 [Abstract] [Full Text]  
  • Hasenbein, M. E., Warner, J. E., Lambert, K. G., Cole, S. E., Onderdonk, A. B., McAdam, A. J. (2004). Detection of Multiple Macrolide- and Lincosamide-Resistant Strains of Streptococcus pyogenes from Patients in the Boston Area. J. Clin. Microbiol. 42: 1559-1563 [Abstract] [Full Text]  
  • Hsueh, P.-R., Teng, L.-J., Lee, C.-M., Huang, W.-K., Wu, T.-L., Wan, J.-H., Yang, D., Shyr, J.-M., Chuang, Y.-C., Yan, J.-J., Lu, J.-J., Wu, J.-J., Ko, W.-C., Chang, F.-Y., Yang, Y.-C., Lau, Y.-J., Liu, Y.-C., Leu, H.-S., Liu, C.-Y., Luh, K.-T. (2003). Telithromycin and Quinupristin-Dalfopristin Resistance in Clinical Isolates of Streptococcus pyogenes: SMART Program 2001 Data. Antimicrob. Agents Chemother. 47: 2152-2157 [Abstract] [Full Text]  
  • Kozlov, R. S., Bogdanovitch, T. M., Appelbaum, P. C., Ednie, L., Stratchounski, L. S., Jacobs, M. R., Bozdogan, B. (2002). Antistreptococcal Activity of Telithromycin Compared with Seven Other Drugs in Relation to Macrolide Resistance Mechanisms in Russia. Antimicrob. Agents Chemother. 46: 2963-2968 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»