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Antimicrobial Agents and Chemotherapy, February 2002, p. 578-581, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.578-581.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Rates and Extents of Antifungal Activities of Amphotericin B, Flucytosine, Fluconazole, and Voriconazole against Candida lusitaniae Determined by Microdilution, Etest, and Time-Kill Methods

Erika J. Ernst,* Keiko Yodoi, Ellen E. Roling, and Michael E. Klepser

College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242

Received 22 May 2001/ Returned for modification 20 August 2001/ Accepted 5 November 2001

Amphotericin B, flucytosine, fluconazole, and voriconazole alone and in combination were evaluated against isolates of Candida lusitaniae. MICs were determined by broth microdilution and Etest, and time-kill studies were conducted. Amphotericin B resulted in fungicidal activity against most isolates, whereas fluconazole, voriconazole, and flucytosine produced primarily fungistatic activities. The addition of flucytosine to amphotericin B resulted in a faster rate and greater extent of kill for isolates for which the MICs of amphotericin B were elevated.

* Corresponding author. Mailing address: The University of Iowa College of Pharmacy, S-428 Pharmacy Bldg., Iowa City, IA 52242-1112. Phone: (319) 335-8785. Fax: (319) 353-5646. E-mail: erika-ernst{at}uiowa.edu..

Antimicrobial Agents and Chemotherapy, February 2002, p. 578-581, Vol. 46, No. 2
0066-4804/01/$04.00+0     DOI: 10.1128/AAC.46.2.578-581.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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