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Antimicrobial Agents and Chemotherapy, March 2002, p. 863-865, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.863-865.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Mutator Bacteria as a Risk Factor in Treatment of Infectious Diseases{dagger}

Antoine Giraud,1,2 Ivan Matic,2 Miroslav Radman,2 Michel Fons,1 and François Taddei2*

UEPSD-FBI, Bat 440-CRJ-Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas,1 E9916, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine "Necker-Enfants Malades," Université René Descartes Paris V, 75015 Paris, France2

Received 2 July 2001/ Returned for modification 4 September 2001/ Accepted 19 November 2001

We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator alleles' high mutation rates, the initial treatment failure increases the probability of failures in subsequent treatments with other drugs.

* Corresponding author. Mailing address: E9916, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine "Necker-Enfants Malades," Université René Descartes Paris V, 156 rue de Vaugirard, 75015 Paris, France. Phone: 33 (0) 1 40 61 53 23. Fax: 33 (0) 1 40 61 53 24. E-mail: taddei{at}necker.fr.

{dagger} Dedicated to the memory of J. Bjorkman.

Antimicrobial Agents and Chemotherapy, March 2002, p. 863-865, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.863-865.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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