This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldstein, E. J. C.
Right arrow Articles by Fernandez, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldstein, E. J. C.
Right arrow Articles by Fernandez, H.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, March 2002, p. 866-870, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.866-870.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of the Des-Fluoro(6) Quinolone BMS-284756 against Aerobic and Anaerobic Pathogens Isolated from Skin and Soft Tissue Animal and Human Bite Wound Infections

Ellie J. C. Goldstein,1,2* Diane M. Citron,2 C. Vreni Merriam,2 Yumi A. Warren,2 Kerin L. Tyrrell,2 and Helen Fernandez2

R. M. Alden Research Laboratory, Santa Monica-University of California, Los Angeles, Medical Center, Santa Monica, California 90404,2 the University of California, Los Angeles, School of Medicine, Los Angeles, California 900731

Received 16 April 2001/ Returned for modification 29 October 2001/ Accepted 21 November 2001

BMS-284756, a new des-fluoro(6) quinolone, was very active against 240 aerobic and 180 anaerobic isolates from bite victims. It inhibited 403 of 420 (96%) isolates, including those of Moraxella spp., CDC group EF-4, and Eikenella corrodens at <=2 µg/ml and those of all Pasteurella spp. and Bergeyella zoohelcum at <=0.015 µg/ml. Fusobacterium russii and 6 of 11 Fusobacterium nucleatum isolates of animal bite origin were resistant, but isolates of human bite origin were susceptible, which suggests that they were of a different subspecies.

* Corresponding author. Mailing address: 2021 Santa Monica Blvd., Suite 740 East, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: EJCGMD{at}aol.com.

Antimicrobial Agents and Chemotherapy, March 2002, p. 866-870, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.866-870.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Edmiston, C. E. Jr, Krepel, C. J., Kehl, K. S., Seabrook, G. R., Somberg, L. B., Almassi, G. H., Smith, T. L., Loehrl, T. A., Brown, K. R., Lewis, B. D., Towne, J. B. (2005). Comparative in vitro antimicrobial activity of a novel quinolone, garenoxacin, against aerobic and anaerobic microbial isolates recovered from general, vascular, cardiothoracic and otolaryngologic surgical patients. J Antimicrob Chemother 56: 872-878 [Abstract] [Full Text]  
  • Conrads, G., Citron, D. M., Goldstein, E. J. C. (2005). Genetic Determinant of Intrinsic Quinolone Resistance in Fusobacterium canifelinum. Antimicrob. Agents Chemother. 49: 434-437 [Abstract] [Full Text]  
  • Liebetrau, A., Rodloff, A. C., Behra-Miellet, J., Dubreuil, L. (2003). In Vitro Activities of a New Des-Fluoro(6) Quinolone, Garenoxacin, against Clinical Anaerobic Bacteria. Antimicrob. Agents Chemother. 47: 3667-3671 [Abstract] [Full Text]  
  • Credito, K. L., Jacobs, M. R., Appelbaum, P. C. (2003). Time-Kill Studies of the Antianaerobe Activity of Garenoxacin Compared with Those of Nine Other Agents. Antimicrob. Agents Chemother. 47: 1399-1402 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»