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Antimicrobial Agents and Chemotherapy, March 2002, p. 896-899, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.896-899.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Stable Concentrations of Zidovudine, Stavudine, Lamivudine, Abacavir, and Nevirapine in Serum and Cerebrospinal Fluid during 2 Years of Therapy

Rieneke M. E. van Praag,1 Elisabeth C. M. van Weert,1 Rolf P. G van Heeswijk,1 Xiao-Jian Zhou,2 Jean-Pierre Sommadossi,2 Suzanne Jurriaans,3 Joep M. A. Lange,1,3 Richard M. W. Hoetelmans,4 and Jan M. Prins1*

National Aids Therapy Evaluation Center (NATEC), Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS,1 Department of Human Retrovirology, Academic Medical Center, University of Amsterdam,3 Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands,4 Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama2

Received 19 July 2001/ Returned for modification 1 November 2001/ Accepted 17 December 2001

For a number of antiretroviral drugs, prolonged suppression of viral replication is related to drug exposure. Therefore, it is important to maintain stable concentrations during prolonged therapy. While studies suggest that saquinavir concentrations decrease over time, we show that concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid are stable during 2 years of therapy.

* Corresponding author. Mailing address: Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Room F4-217, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-(0)20-5664380. Fax: 31-(0)20-6972286. E-mail: J.M.Prins{at}amc.uva.nl.

Antimicrobial Agents and Chemotherapy, March 2002, p. 896-899, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.896-899.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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