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Antimicrobial Agents and Chemotherapy, April 2002, p. 1093-1097, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1093-1097.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

mar Operon Involved in Multidrug Resistance of Enterobacter aerogenes

Renaud Chollet, Claude Bollet, Jacqueline Chevalier, Monique Malléa, Jean-Marie Pagès, and Anne Davin-Regli*

Enveloppe Bactérienne, Antibiotiques et Colonisation, CJF 9606-EA 2197, Facultés de Médecine et Pharmacie, Université de la Méditerranée, 13385 Marseille Cedex 05, France

Received 19 July 2001/ Returned for modification 1 October 2001/ Accepted 20 November 2001

We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin.

* Corresponding author. Mailing address: CJF 9606 - EA 2197, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France. Phone: 00 33 (0)4 91 32 45 29. Fax: 00 33 (0)4 91 32 46 06. E-mail: Anne.Regli{at}medecine.univ-mrs.fr.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1093-1097, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1093-1097.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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