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Antimicrobial Agents and Chemotherapy, April 2002, p. 1098-1100, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1098-1100.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

First Description of Klebsiella pneumoniae Harboring CTX-M ß-Lactamases (CTX-M-14 and CTX-M-3) in Taiwan

Wen Liang Yu,1,2 Patricia L. Winokur,1,3 Diana L. Von Stein,3 Michael A. Pfaller,1 Jen Hsien Wang,2 and Ronald N. Jones1,4*

University of Iowa College of Medicine,1 The Veterans Affairs Medical Center, Iowa City,3 The JONES Group/JMI Laboratories, North Liberty, Iowa,4 China Medical College Hospital, Taichung City, Taiwan2

Received 18 July 2001/ Returned for modification 12 November 2001/ Accepted 18 January 2002

Klebsiella pneumoniae isolates from Taiwan medical centers (50 strains; 1998 to 2000) with a CTX-M resistance phenotype (ceftazidime susceptible and ceftriaxone or cefotaxime nonsusceptible) were selected for initial isoelectric focusing analysis. ß-Lactamases with pIs of 7.9 (n = 22) and 8.4 (n = 28) in addition to 5.4 and/or 7.6 were detected. DNA gene sequencing identified the ß-lactamases with pIs of 7.9 and 8.4 as CTX-M-14 and CTX-M-3, respectively. Molecular typing suggested inter- and intrahospital clonal dissemination of these Taiwanese CTX-M-producing Klebsiella strains.

* Corresponding author. Mailing address: The JONES Group/JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 665-3371. E-mail: ronald-jones{at}jmilabs.com.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1098-1100, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1098-1100.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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