This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsuchihashi, Y.
Right arrow Articles by Nagatake, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsuchihashi, Y.
Right arrow Articles by Nagatake, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2002, p. 1101-1104, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1101-1104.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Fourteen-Member Macrolides Suppress Interleukin-8 Production but Do Not Promote Apoptosis of Activated Neutrophils

Yoshiko Tsuchihashi,1,{dagger} Kazunori Oishi,1* Hiroyuki Yoshimine,1 Shoichi Suzuki,2 Atsushi Kumatori,2 Toshiaki Sunazuka,3 Satoshi Omura,3 Kouji Matsushima,4 and Tsuyoshi Nagatake1

Departments of Internal Medicine,1 Biochemistry, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523,2 The Kitasato Institute,3 Department of Molecular Preventive Medicine, The University of Tokyo, Tokyo, Japan4

Received 29 June 2001/ Returned for modification 15 October 2001/ Accepted 31 December 2001

A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest that 14-member macrolides achieve clinical efficacy for chronic airway diseases partly by suppressing IL-8 production by activated neutrophils, but not by enhancing apoptosis in these cells.

* Corresponding author. Mailing address: Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Phone: (81) 95-849-7842. Fax: (81) 95-849-7843. E-mail: oishi-k{at}net.nagasaki-u.ac.jp.

{dagger} Present address: Pulmonary Department, National Sanatorium, Kawatana Hospital, 2005-1, Shimokumi, Kawatana 859-3615, Japan.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1101-1104, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1101-1104.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yamasawa, H., Oshikawa, K., Ohno, S., Sugiyama, Y. (2004). Macrolides Inhibit Epithelial Cell-Mediated Neutrophil Survival by Modulating Granulocyte Macrophage Colony-Stimulating Factor Release. Am. J. Respir. Cell Mol. Bio. 30: 569-575 [Abstract] [Full Text]  
  • Watt, A P, Brown, V, Courtney, J, Kelly, M, Garske, L, Elborn, J S, Ennis, M (2004). Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis. Thorax 59: 231-236 [Abstract] [Full Text]  
  • Yamaryo, T., Oishi, K., Yoshimine, H., Tsuchihashi, Y., Matsushima, K., Nagatake, T. (2003). Fourteen-Member Macrolides Promote the Phosphatidylserine Receptor-Dependent Phagocytosis of Apoptotic Neutrophils by Alveolar Macrophages. Antimicrob. Agents Chemother. 47: 48-53 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»