This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tsuchihashi, Y. Articles by Nagatake, T. Search for Related Content PubMed PubMed Citation Articles by Tsuchihashi, Y. Articles by Nagatake, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2002, p. 1101-1104, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1101-1104.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Fourteen-Member Macrolides Suppress Interleukin-8 Production but Do Not Promote Apoptosis of Activated Neutrophils

Yoshiko Tsuchihashi,^1, Kazunori Oishi,^1* Hiroyuki Yoshimine,¹ Shoichi Suzuki,² Atsushi Kumatori,² Toshiaki Sunazuka,³ Satoshi Omura,³ Kouji Matsushima,⁴ and Tsuyoshi Nagatake¹

Departments of Internal Medicine,¹ Biochemistry, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523,² The Kitasato Institute,³ Department of Molecular Preventive Medicine, The University of Tokyo, Tokyo, Japan⁴

Received 29 June 2001/ Returned for modification 15 October 2001/ Accepted 31 December 2001

A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest that 14-member macrolides achieve clinical efficacy for chronic airway diseases partly by suppressing IL-8 production by activated neutrophils, but not by enhancing apoptosis in these cells.

Present address: Pulmonary Department, National Sanatorium, Kawatana Hospital, 2005-1, Shimokumi, Kawatana 859-3615, Japan.

This article has been cited by other articles:

• Yamasawa, H., Oshikawa, K., Ohno, S., Sugiyama, Y. (2004). Macrolides Inhibit Epithelial Cell-Mediated Neutrophil Survival by Modulating Granulocyte Macrophage Colony-Stimulating Factor Release. Am. J. Respir. Cell Mol. Bio. 30: 569-575 [Abstract] [Full Text]  
• Watt, A P, Brown, V, Courtney, J, Kelly, M, Garske, L, Elborn, J S, Ennis, M (2004). Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis. Thorax 59: 231-236 [Abstract] [Full Text]  
• Yamaryo, T., Oishi, K., Yoshimine, H., Tsuchihashi, Y., Matsushima, K., Nagatake, T. (2003). Fourteen-Member Macrolides Promote the Phosphatidylserine Receptor-Dependent Phagocytosis of Apoptotic Neutrophils by Alveolar Macrophages. Antimicrob. Agents Chemother. 47: 48-53 [Abstract] [Full Text]