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Antimicrobial Agents and Chemotherapy, April 2002, p. 1122-1124, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1122-1124.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Combination of Quinupristin-Dalfopristin (Synercid) and Rifampin Is Highly Synergistic in Experimental Staphylococcus aureus Joint Prosthesis Infection

Azzam Saleh-Mghir,1 Nourdine Ameur,1 Claudette Muller-Serieys,2 Farid Ismael,1 Françoise Lemaitre,2 Laurent Massias,1 Céline Feger,3 Rémy Bléton,1 and Anne-Claude Crémieux1*

INSERM EMI-U 9933,1 Microbiology, Hôpital Bichat-Claude Bernard,2 Aventis Pharma, Paris, France3

Received 2 August 2001/ Returned for modification 10 October 2001/ Accepted 23 December 2001

We compared the efficacies of quinupristin-dalfopristin (Q-D; 30 mg/kg of body weight every 8 h) and vancomycin (60 mg/kg twice daily), alone or in combination with rifampin (10 mg/kg twice daily), in a rabbit model of methicillin-resistant Staphylococcus aureus knee prosthesis infection. In contrast to vancomycin, Q-D significantly reduced the mean log10 CFU per gram of bone versus that for the controls. The combination of rifampin with either Q-D or vancomycin was significantly more effective than monotherapy.

* Corresponding author. Mailing address: Hôpital Bichat-Claude Bernard, 46 rue Henri Huchard, 75877 Paris Cedex 18, France. Phone: 33 (1) 40 25 87 00. Fax: 33 (1) 40 25 88 45. E-mail: anne-claude.cremieux{at}bch.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1122-1124, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1122-1124.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Perlroth, J., Kuo, M., Tan, J., Bayer, A. S., Miller, L. G. (2008). Adjunctive Use of Rifampin for the Treatment of Staphylococcus aureus Infections: A Systematic Review of the Literature. Arch Intern Med 168: 805-819 [Abstract] [Full Text]  
  • Darley, E. S. R., MacGowan, A. P. (2004). Antibiotic treatment of Gram-positive bone and joint infections. J Antimicrob Chemother 53: 928-935 [Abstract] [Full Text]  
  • Parra-Ruiz, J., Martinez, M., Antelo-Lorenzo, R., Hernandez-Quero, J. (2004). Antimicrobials in the treatment of orthopaedic prosthetic infections. J Antimicrob Chemother 53: 886-887 [Full Text]  
  • Ismael, F., Bleton, R., Saleh-Mghir, A., Dautrey, S., Massias, L., Cremieux, A.-C. (2003). Teicoplanin-Containing Cement Spacers for Treatment of Experimental Staphylococcus aureus Joint Prosthesis Infection. Antimicrob. Agents Chemother. 47: 3365-3367 [Abstract] [Full Text]  


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