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Antimicrobial Agents and Chemotherapy, April 2002, p. 1141-1143, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1141-1143.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of a New Des-Fluoroquinolone, BMS 284756, and Seven Other Antimicrobial Agents against 151 Isolates of Eikenella corrodens

The R. M. Alden Research Laboratory and UCLA Medical Center, Santa Monica, California 90404

Received 20 August 2001/ Returned for modification 1 November 2001/ Accepted 14 November 2001

The des-fluoroquinolone BMS 284756 was active in vitro against all 151 clinical strains of Eikenella corrodens at a MIC of 0.25 µg/ml and was comparable in activity to moxifloxacin and levofloxacin. The MIC at which 90% of the isolates were inhibited by penicillin G was 2 µg/ml; MICs for 8.6% of the strains (13 of 151) were 4 µg/ml, including for two beta-lactamase-producing isolates. Amoxicillin-clavulanate and ampicillin-sulbactam inhibited all strains at a MIC of 1 µg/ml.

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