This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barlow, M.
Right arrow Articles by Hall, B. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barlow, M.
Right arrow Articles by Hall, B. G.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 2002, p. 1190-1198, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1190-1198.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Origin and Evolution of the AmpC ß-Lactamases of Citrobacter freundii

Miriam Barlow and Barry G. Hall*

Biology Department, University of Rochester, Rochester, New York

Received 24 July 2001/ Returned for modification 19 November 2001/ Accepted 19 January 2002

To determine whether the widespread clinical use of ß-lactams has been selective for Citrobacter freundii-derived alleles of plasmid ampC genes, we generated a Bayesian consensus phylogeny of the published ampC sequences and compared the MICs of 16 ß-lactam antibiotics for Escherichia coli strains containing cloned copies of the C. freundii ampC alleles. We found that for the majority of compounds investigated, there has been essentially no increase in ß-lactam resistance conferred by those alleles. We also found that ampC alleles from the chromosomes of two ß-lactam-sensitive C. freundii strains isolated in the 1920s, before the clinical use of antibiotics, were as effective at providing ß-lactam resistance in E. coli as were the plasmid-borne alleles from ß-lactam-resistant clinical isolates. These results suggest that selection for increased resistance to ß-lactam antibiotics has not been a significant force directing the evolution of the C. freundii ampC alleles found in ß-lactam-resistant clinical isolates.

* Corresponding author. Mailing address: Biology Department, Hutchison Hall, University of Rochester, Rochester, NY 14627-0211. Phone: (716) 275-0721. Fax: (716) 275-2070. E-mail: drbh{at}mail.rochester.edu.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1190-1198, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1190-1198.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Verdet, C., Gautier, V., Chachaty, E., Ronco, E., Hidri, N., Decre, D., Arlet, G. (2009). Genetic Context of Plasmid-Carried blaCMY-2-Like Genes in Enterobacteriaceae. Antimicrob. Agents Chemother. 53: 4002-4006 [Abstract] [Full Text]  
  • Daniels, J. B., Call, D. R., Hancock, D., Sischo, W. M., Baker, K., Besser, T. E. (2009). Role of Ceftiofur in Selection and Dissemination of blaCMY-2-Mediated Cephalosporin Resistance in Salmonella enterica and Commensal Escherichia coli Isolates from Cattle. Appl. Environ. Microbiol. 75: 3648-3655 [Abstract] [Full Text]  
  • Zioga, A., Whichard, J. M., Kotsakis, S. D., Tzouvelekis, L. S., Tzelepi, E., Miriagou, V. (2009). CMY-31 and CMY-36 Cephalosporinases Encoded by ColE1-Like Plasmids. Antimicrob. Agents Chemother. 53: 1256-1259 [Abstract] [Full Text]  
  • Jacoby, G. A. (2009). AmpC {beta}-Lactamases. Clin. Microbiol. Rev. 22: 161-182 [Abstract] [Full Text]  
  • Singer, R. S., Patterson, S. K., Wallace, R. L. (2008). Effects of Therapeutic Ceftiofur Administration to Dairy Cattle on Escherichia coli Dynamics in the Intestinal Tract. Appl. Environ. Microbiol. 74: 6956-6962 [Abstract] [Full Text]  
  • Haldorsen, B., Aasnaes, B., Dahl, K. H., Hanssen, A.-M., Simonsen, G. S., Walsh, T. R., Sundsfjord, A., Lundblad, E. W. (2008). The AmpC phenotype in Norwegian clinical isolates of Escherichia coli is associated with an acquired ISEcp1-like ampC element or hyperproduction of the endogenous AmpC. J Antimicrob Chemother 62: 694-702 [Abstract] [Full Text]  
  • Li, Y., Li, Q., Du, Y., Jiang, X., Tang, J., Wang, J., Li, G., Jiang, Y. (2008). Prevalence of Plasmid-Mediated AmpC {beta}-Lactamases in a Chinese University Hospital from 2003 to 2005: First Report of CMY-2-Type AmpC {beta}-Lactamase Resistance in China. J. Clin. Microbiol. 46: 1317-1321 [Abstract] [Full Text]  
  • Zhang, R., Yang, L., Cai, J. C., Zhou, H. W., Chen, G.-X. (2008). High-level carbapenem resistance in a Citrobacter freundii clinical isolate is due to a combination of KPC-2 production and decreased porin expression. J Med Microbiol 57: 332-337 [Abstract] [Full Text]  
  • Daniels, J. B., Call, D. R., Besser, T. E. (2007). Molecular Epidemiology of blaCMY-2 Plasmids Carried by Salmonella enterica and Escherichia coli Isolates from Cattle in the Pacific Northwest. Appl. Environ. Microbiol. 73: 8005-8011 [Abstract] [Full Text]  
  • Montero, C. I., Johnson, M. R., Chou, C.-J., Conners, S. B., Geouge, S. G., Tachdjian, S., Nichols, J. D., Kelly, R. M. (2007). Responses of Wild-Type and Resistant Strains of the Hyperthermophilic Bacterium Thermotoga maritima to Chloramphenicol Challenge. Appl. Environ. Microbiol. 73: 5058-5065 [Abstract] [Full Text]  
  • Liu, L., Pearl, D. K. (2007). Species Trees from Gene Trees: Reconstructing Bayesian Posterior Distributions of a Species Phylogeny Using Estimated Gene Tree Distributions. Syst Biol 56: 504-514 [Abstract] [Full Text]  
  • Whalen, J. G., Mully, T. W., English, J. C. III (2007). Spontaneous Citrobacter freundii Infection in an Immunocompetent Patient. Arch Dermatol 143: 124-125 [Full Text]  
  • Jacoby, G. A. (2006). {beta}-Lactamase Nomenclature.. Antimicrob. Agents Chemother. 50: 1123-1129 [Full Text]  
  • Kang, M.-S., Besser, T. E., Call, D. R. (2006). Variability in the Region Downstream of the blaCMY-2 {beta}-Lactamase Gene in Escherichia coli and Salmonella enterica Plasmids.. Antimicrob. Agents Chemother. 50: 1590-1593 [Abstract] [Full Text]  
  • Su, L.-H., Chen, H.-L., Chia, J.-H., Liu, S.-Y., Chu, C., Wu, T.-L., Chiu, C.-H. (2006). Distribution of a transposon-like element carrying blaCMY-2 among Salmonella and other Enterobacteriaceae. J Antimicrob Chemother 57: 424-429 [Abstract] [Full Text]  
  • Fevre, C., Jbel, M., Passet, V., Weill, F.-X., Grimont, P. A. D., Brisse, S. (2005). Six Groups of the OXY {beta}-Lactamase Evolved over Millions of Years in Klebsiella oxytoca. Antimicrob. Agents Chemother. 49: 3453-3462 [Abstract] [Full Text]  
  • Lau, S. K. P., Ho, P.-l., Li, M. W. S., Tsoi, H.-w., Yung, R. W. H., Woo, P. C. Y., Yuen, K.-y. (2005). Cloning and Characterization of a Chromosomal Class C {beta}-Lactamase and Its Regulatory Gene in Laribacter hongkongensis. Antimicrob. Agents Chemother. 49: 1957-1964 [Abstract] [Full Text]  
  • Literacka, E., Empel, J., Baraniak, A., Sadowy, E., Hryniewicz, W., Gniadkowski, M. (2004). Four Variants of the Citrobacter freundii AmpC-Type Cephalosporinases, Including Novel Enzymes CMY-14 and CMY-15, in a Proteus mirabilis Clone Widespread in Poland. Antimicrob. Agents Chemother. 48: 4136-4143 [Abstract] [Full Text]  
  • Nasim, K., Elsayed, S., Pitout, J. D. D., Conly, J., Church, D. L., Gregson, D. B. (2004). New Method for Laboratory Detection of AmpC {beta}-Lactamases in Escherichia coli and Klebsiella pneumoniae. J. Clin. Microbiol. 42: 4799-4802 [Abstract] [Full Text]  
  • Miriagou, V., Tzouvelekis, L. S., Villa, L., Lebessi, E., Vatopoulos, A. C., Carattoli, A., Tzelepi, E. (2004). CMY-13, a Novel Inducible Cephalosporinase Encoded by an Escherichia coli Plasmid. Antimicrob. Agents Chemother. 48: 3172-3174 [Abstract] [Full Text]  
  • Haeggman, S., Lofdahl, S., Paauw, A., Verhoef, J., Brisse, S. (2004). Diversity and Evolution of the Class A Chromosomal Beta-Lactamase Gene in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 48: 2400-2408 [Abstract] [Full Text]  
  • Hossain, A., Reisbig, M. D., Hanson, N. D. (2004). Plasmid-encoded functions compensate for the biological cost of AmpC overexpression in a clinical isolate of Salmonella typhimurium. J Antimicrob Chemother 53: 964-970 [Abstract] [Full Text]  
  • Nakano, R., Okamoto, R., Nakano, Y., Kaneko, K., Okitsu, N., Hosaka, Y., Inoue, M. (2004). CFE-1, a Novel Plasmid-Encoded AmpC {beta}-Lactamase with an ampR Gene Originating from Citrobacter freundii. Antimicrob. Agents Chemother. 48: 1151-1158 [Abstract] [Full Text]  
  • Corvec, S., Caroff, N., Espaze, E., Giraudeau, C., Drugeon, H., Reynaud, A. (2003). AmpC cephalosporinase hyperproduction in Acinetobacter baumannii clinical strains. J Antimicrob Chemother 52: 629-635 [Abstract] [Full Text]  
  • Hanson, N. D. (2003). AmpC {beta}-lactamases: what do we need to know for the future?. J Antimicrob Chemother 52: 2-4 [Full Text]  
  • Lee, S. H., Kim, J. Y., Shin, S. H., An, Y. J., Choi, Y. W., Jung, Y. C., Jung, H. I., Sohn, E. S., Jeong, S. H., Lee, K. J. (2003). Dissemination of SHV-12 and Characterization of New AmpC-Type Beta-Lactamase Genes among Clinical Isolates of Enterobacter Species in Korea. J. Clin. Microbiol. 41: 2477-2482 [Abstract] [Full Text]  
  • Barlow, M., Hall, B. G. (2003). Experimental Prediction of the Evolution of Cefepime Resistance From the CMY-2 AmpC {beta}-Lactamase. Genetics 164: 23-29 [Abstract] [Full Text]  
  • Salipante, S. J., Hall, B. G. (2003). Determining the Limits of the Evolutionary Potential of an Antibiotic Resistance Gene. Mol Biol Evol 20: 653-659 [Abstract] [Full Text]  
  • Manchanda, V., Singh, N. P. (2003). Occurrence and detection of AmpC {beta}-lactamases among Gram-negative clinical isolates using a modified three-dimensional test at Guru Tegh Bahadur Hospital, Delhi, India. J Antimicrob Chemother 51: 415-418 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»