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Antimicrobial Agents and Chemotherapy, May 2002, p. 1269-1272, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1269-1272.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Characterization of Plasmids Carrying CMY-2 from Expanded-Spectrum Cephalosporin-Resistant Salmonella Strains Isolated in the United States between 1996 and 1998

A. Carattoli,1 F. Tosini,2 W. P. Giles,3 M. E. Rupp,3 S. H. Hinrichs,4 F. J. Angulo,5 T. J. Barrett,5 and P. D. Fey3,4*

Laboratory of Bacteriology and Mycology,1 Laboratory of Cellular Biology, Istituto Superiore di Sanità, 00161 Rome, Italy,2 Department of Internal Medicinethe,3 Nebraska Public Health Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska,4 Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia5

Received 11 May 2001/ Returned for modification 24 July 2001/ Accepted 24 January 2002

Sequencing of DNA from 15 expanded-spectrum cephalosporin (e.g., ceftriaxone)-resistant Salmonella isolates obtained in the United States revealed that resistance to ceftriaxone in all isolates was mediated by cmy-2. Hybridization patterns revealed three plasmid structures containing cmy-2 in these 15 isolates. These data suggest that the spread of cmy-2 among Salmonella strains is occurring through mobilization of the cmy-2 gene into different plasmid backbones and consequent horizontal transfer by conjugation.

* Corresponding author. Mailing address: Departments of Internal Medicine and Pathology and Microbiology, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198-5400. Phone: (402) 559-2122. Fax: (402) 559-5581. E-mail: pfey{at}unmc.edu.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1269-1272, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1269-1272.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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