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Antimicrobial Agents and Chemotherapy, May 2002, p. 1553-1556, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1553-1556.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Activities of New Fluoroquinolones, Ketolides, and Other Antimicrobials against Blood Culture Isolates of Viridans Group Streptococci from across Canada, 2000

Andrea S. Gershon,1 Joyce C. S. de Azavedo,1,2 Allison McGeer,1,2 Krystyna I. Ostrowska,3 Deirdre Church,4 Daryl J. Hoban,5 Godfrey K. M. Harding,6 Karl Weiss,7 Lewis Abbott,8 Fiona Smaill,9 Marie Gourdeau,10 Gilles Murray,10 Donald E. Low,2,3* and Canadian Bacterial Surveillance Network{dagger}

University of Toronto,1 Toronto Medical Laboratories and Mount Sinai Hospital, Toronto,2 Trillium Health Centre, Mississauga,3 Hamilton Health Sciences Centre, Hamilton, Ontario,9 Calgary Laboratory Services, Calgary, Alberta,4 Health Sciences Centre,5 St. Boniface General Hospital, Winnipeg, Manitoba,6 Hopital Maisonneuve-Rosemont, University of Montreal, Montreal,7 Hopital de l'Enfant-Jesus, Quebec City, Quebec,10 Queen Elizabeth Hospital, Charlottetown, Prince Edward Island, Canada8

Received 13 August 2001/ Returned for modification 29 November 2001/ Accepted 24 January 2002

The rates of nonsusceptibility to penicillin, erythromycin, and clindamycin of 191 blood culture isolates of viridans group streptococci collected from across Canada in 2000 were 36, 42, and 10%, respectively. Although 8% of the strains were resistant to ciprofloxacin (MIC >= 4 µg/ml), the MICs of gemifloxacin, BMS 284756, telithromycin, and ABT 773 at which 90% of the strains were inhibited were 0.06, 0.06, 0.12, and 0.03 µg/ml, respectively.

* Corresponding author. Mailing address: Department of Microbiology Rm. 1483, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario M5G 1X5, Canada. Phone: (416) 586-4435. Fax: (416) 586-8746. E-mail: dlow{at}mtsinai.on.ca.

{dagger} Members are listed in the Appendix.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1553-1556, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1553-1556.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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