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Antimicrobial Agents and Chemotherapy, May 2002, p. 1571-1573, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1571-1573.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

rpoB Mutation Conferring Rifampin Resistance in Streptococcus pyogenes

Hélène Aubry-Damon,,{dagger} Marc Galimand, Guy Gerbaud, and Patrice Courvalin*

Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France

Received 18 September 2000/ Returned for modification 30 March 2001/ Accepted 24 January 2002

Streptococcus pyogenes BM4478 and Staphylococcus aureus BM4479 were isolated from a patient undergoing rifampin therapy. High-level resistance to rifampin was due to the following mutations in the rpoB gene: Ser522Leu in strain BM4478 and His526Asn and Ser574Leu in strain BM4479.

* Corresponding author. Mailing address: Unité des Agents Antibactériens, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Phone: 33 1 45 68 83 20. Fax: 33 1 46 68 83 19. E-mail: pcourval{at}pasteur.fr.

{dagger} Present address: Département des Maladies Infectieuses, Institut de Veille Sanitaire, 12 rue du Val d'Osne, 94415 Saint Maurice, France.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1571-1573, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1571-1573.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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