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Antimicrobial Agents and Chemotherapy, May 2002, p. 1577-1580, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1577-1580.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Outbreak of Infections Caused by Enterobacter cloacae Producing the Integron-Associated ß-Lactamase IBC-1 in a Neonatal Intensive Care Unit of a Greek Hospital

Georgia Kartali,1 Eva Tzelepi,2 Spyros Pournaras,3 Constantina Kontopoulou,1 Fanourios Kontos,3 Danai Sofianou,1 Antonios N. Maniatis,3 and Athanassios Tsakris4*

Department of Microbiology, Hippokration General Hospital,1 Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki,4 Department of Bacteriology, Hellenic Pasteur Institute, Athens,2 Department of Medical Microbiology, University of Thessalia, Larissa, Greece3

Received 22 June 2001/ Returned for modification 23 November 2001/ Accepted 9 February 2002

Nineteen of 27 ceftazidime-resistant Enterobacter cloacae isolates from a neonatal intensive care unit in Thessaloniki, Greece, had genes coding for the novel extended-spectrum ß-lactamase IBC-1; 18 of those 19 harbored similar conjugative plasmids and belonged to two distinct genetic lineages. A synergy test with ceftazidime and imipenem enabled us to identify five unrelated blaIBC-1-carrying E. cloacae isolates from other wards of the hospital. It seems that this integron-associated gene is capable of dispersing both by clonal spread and by gene dissemination.

* Corresponding author. Mailing address: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece. Phone: 30 310 99 90 91. Fax: 30 310 99 91 49. E-mail: atsakris{at}med.auth.gr.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1577-1580, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1577-1580.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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