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Antimicrobial Agents and Chemotherapy, May 2002, p. 1583-1585, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1583-1585.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Free and Lipid Formulations of Amphotericin B and Nystatin against Clinical Isolates of Coccidioides immitis at Various Saprobic Stages

Gloria M. González,1,2* Rolando Tijerina,2 Deanna A. Sutton,1 John R. Graybill,1,3 and Michael G. Rinaldi1,3

Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center at San Antonio,1 Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78229-3900,3 Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México2

Received 31 January 2002/ Accepted 5 February 2002

We investigated the susceptibilities of hyphal, mixed hyphal, ungerminated arthroconidial, and germinated arthroconidial populations of Coccidioides immitis to lipid formulations of amphotericin B and nystatin and their conventional preparations, utilizing the National Committee for Clinical Laboratory Standards M38-P broth macrodilution method. The differences in effects of the three different growth stages of the saprobic phase of C. immitis on the MIC/minimum lethal concentration (MLC) ratio were not statistically significant for any of the antifungal agents tested. These results suggest that either inocula could be used for in vitro susceptibility studies with C. immitis.

* Corresponding author. Mailing address: Facultad de Medicina, Universidad Autónoma de Nuevo León, Departamento de Microbiología, Madero y Dr. Eduardo A. Pequeño s/n, Colonia Mitras Centro, Monterrey, N.L. México. 64460. Phone: (52) 8329 4166. Fax: (52) 8348 5477. E-mail: gmglez{at}yahoo.com.mx.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1583-1585, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1583-1585.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fernandez-Torres, B., Inza, I., Guarro, J. (2003). Comparison of In Vitro Antifungal Susceptibilities of Conidia and Hyphae of Dermatophytes with Thick-Wall Macroconidia. Antimicrob. Agents Chemother. 47: 3371-3372 [Full Text]  


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