This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cottagnoud, P.
Right arrow Articles by Täuber, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cottagnoud, P.
Right arrow Articles by Täuber, M. G.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 2002, p. 1607-1609, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1607-1609.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Gemifloxacin Is Efficacious against Penicillin-Resistant and Quinolone-Resistant Pneumococci in Experimental Meningitis

Philippe Cottagnoud,1* Fernando Acosta,2 Marianne Cottagnoud,2 and Martin G. Täuber3

Department of Internal Medicine, Inselspital,1 Institute of Infectious Diseases, University of Bern, 3010 Bern,3 Department of Internal Medicine, Zieglerspital, 3007 Bern, Switzerland2

Received 5 February 2001/ Returned for modification 27 November 2001/ Accepted 1 February 2002

In experimental rabbit meningitis, gemifloxacin penetrated inflamed meninges well (22 to 33%) and produced excellent bactericidal activity (change in log10 [{Delta}log10] CFU/ml/h, -0.68 ± 0.30 [mean and standard deviation]), even superior to that of the standard regimen of ceftriaxone plus vancomycin (-0.49 ± 0.09 {Delta}log10 CFU/ml/h), in the treatment of meningitis due to a penicillin-resistant pneumococcal strain (MIC, 4 mg/liter). Even against a penicillin- and quinolone-resistant strain, gemifloxacin showed good bactericidal activity (-0.48 ± 0.16 {Delta}log10 CFU/ml/h). The excellent antibacterial activity of gemifloxacin was also confirmed by time-kill assays over 8 h in vitro.

* Corresponding author. Mailing address: Department of Internal Medicine, Inselspital, 3010 Bern, Switzerland. Phone: 41 31 632 2111. Fax: 41 31 632 3847. E-mail: pcottagn{at}insel.ch.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1607-1609, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1607-1609.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Morrissey, I., Tillotson, G. (2004). Activity of gemifloxacin against Streptococcus pneumoniae and Haemophilus influenzae. J Antimicrob Chemother 53: 144-148 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»