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 Previous Article

Antimicrobial Agents and Chemotherapy, May 2002, p. 1617-1618, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1617-1618.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Linezolid against Clostridium difficile

T. Peláez, R. Alonso,* C. Pérez, L. Alcalá, O. Cuevas, and E. Bouza

Microbiology and Infectious Diseases Service, Hospital General Universitario "Gregorio Marañón," Madrid, Spain

Received 6 September 2001/ Returned for modification 30 December 2001/ Accepted 4 February 2002

We examined the in vitro activity of linezolid against Clostridium difficile, including isolates with reduced susceptibility to metronidazole or vancomycin. The MIC at which 50% of the isolates were inhibited (MIC50) and MIC90 were 0.5 and 2 µg/ml, respectively (range, 0.03 to 4 µg/ml). MICs were always <= 4 µg/ml, and thus, all isolates were considered susceptible.

* Corresponding author. Mailing address: Servicio de Microbiologia Claínica y Enfermedades Infecciosas, Hospital General Universitario "Gregorio Marañon," C/Dr. Esquerdo, 46, 28007 Madrid, Spain. Phone: 34-91-5868793. Fax: 34-91-5044906. E-mail: ralonso{at}microb.net.

Antimicrobial Agents and Chemotherapy, May 2002, p. 1617-1618, Vol. 46, No. 5
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.5.1617-1618.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ackermann, G., Degner, A., Cohen, S. H., Silva, J. Jr, Rodloff, A. C. (2003). Prevalence and association of macrolide-lincosamide- streptogramin B (MLSB) resistance with resistance to moxifloxacin in Clostridium difficile. J Antimicrob Chemother 51: 599-603 [Abstract] [Full Text]  
  • Ackermann, G., Adler, D., Rodloff, A. C. (2003). In vitro activity of linezolid against Clostridium difficile. J Antimicrob Chemother 51: 743-745 [Full Text]  


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