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Antimicrobial Agents and Chemotherapy, June 2002, p. 1723-1727, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.1723-1727.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Ravuconazole and Voriconazole Compared with Those of Four Approved Systemic Antifungal Agents against 6,970 Clinical Isolates of Candida spp.

M. A. Pfaller,1,2* S. A. Messer,1 R. J. Hollis,1 R. N. Jones,3 and D. J. Diekema1,4

Departments of Pathology,1 Medicine,4 Epidemiology, University of Iowa College of Medicine, and College of Public Health, Iowa City, Iowa 52242,2 The Jones Group/JMI Laboratories, North Liberty, Iowa 523173

Received 11 December 2001/ Returned for modification 26 February 2002/ Accepted 20 March 2002

The in vitro activities of ravuconazole and voriconazole were compared with those of amphotericin B, flucytosine (5FC), itraconazole, and fluconazole against 6,970 isolates of Candida spp. obtained from over 200 medical centers worldwide. Both ravuconazole and voriconazole were very active against all Candida spp. (MIC at which 90% of the isolates tested are inhibited [MIC90], 0.25 µg/ml; 98% of MICs were <=1 µg/ml); however, a decrease in the activities of both of these agents was noted among isolates that were susceptible-dose dependent (fluconazole MIC, 16 to 32 µg/ml) and resistant (MIC, >= 64 µg/ml) to fluconazole. Candida albicans was the most susceptible species (MIC90 of both ravuconazole and voriconazole, 0.03 µg/ml), and C. glabrata was the least susceptible species (MIC90, 1 to 2 µg/ml). Ravuconazole and voriconazole were each more active in vitro than amphotericin B, 5FC, itraconazole, and fluconazole against all Candida spp. and were the only agents with good in vitro activity against C. krusei. These results provide further evidence for the spectrum and potency of ravuconazole and voriconazole against a large and geographically diverse collection of Candida spp.

* Corresponding author. Mailing address: Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242. Phone: (319) 384-9566. Fax: (319) 356-4916. E-mail: michael-pfaller{at}uiowa.edu.

Antimicrobial Agents and Chemotherapy, June 2002, p. 1723-1727, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.1723-1727.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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