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Antimicrobial Agents and Chemotherapy, June 2002, p. 1971-1973, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC;46.6.1971-1973.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Reducing Mortality in Salmonella enterica Serovar Typhimurium-Infected Mice with a Tripeptidic Serum Fraction

Todd A. Parker,1 Kenneth O. Willeford,1* Suzanne Parker,2 and Karyl Buddington3

Department of Biochemistry and Molecular Biology,1 Department of Agricultural and Biological Engineering,2 Department of Biological Sciences, Mississippi State University, Mississippi State, Mississippi 397623

Received 11 June 2001/ Returned for modification 25 November 2001/ Accepted 6 February 2002

Salmonellosis-induced mortality in female Swiss Webster mice decreased significantly when tripeptidic immunostimulant (TPI) was administered prophylactically. Prophylactic benefits developed in a dose-dependent manner wherein 15 mg of TPI given 1 day before challenge reduced mortality by 70%.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Box 9650, Mississippi State University, Mississippi State, MS 39762. Phone: (662) 325-2651. Fax: (662) 325-8664. E-mail: KOWMSU{at}RA.MSSTATE.EDU.

Antimicrobial Agents and Chemotherapy, June 2002, p. 1971-1973, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC;46.6.1971-1973.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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