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Antimicrobial Agents and Chemotherapy, June 2002, p. 1974-1976, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.1974-1976.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Amphotericin B Formulations Exert Additive Antifungal Activity in Combination with Pulmonary Alveolar Macrophages and Polymorphonuclear Leukocytes against Aspergillus fumigatus

Emmanuel Roilides,1,2 Caron A. Lyman,2 Joanna Filioti,1 Onome Akpogheneta,1 Tin Sein,2 Cristina Gil Lamaignere,1 Ruta Petraitiene,2 and Thomas J. Walsh2*

3rd Department of Pediatrics, University of Thessaloniki, Hippokration Hospital, Thessaloniki GR-54642, Greece,1 Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 208922

Received 18 May 2001/ Returned for modification 14 July 2001/ Accepted 19 February 2002

Deoxycholate amphotericin B (DAMB) and amphotericin B lipid complex (ABLC) additively augmented the fungicidal activity of pulmonary alveolar macrophages against the conidia of Aspergillus fumigatus. DAMB, ABLC, and liposomal amphotericin B similarly displayed additive effects with polymorphonuclear leukocytes in damaging the hyphal elements of A. fumigatus.

* Corresponding author. Mailing address: Immunocompromised Host Section, Pediatric Oncology Branch, Bldg. 10, Rm. 13N240, National Cancer Institute, Bethesda, MD 20892. Phone (301) 402-0023. Fax: (301) 402-0575. E-mail: walsht{at}mail.nih.gov.

Antimicrobial Agents and Chemotherapy, June 2002, p. 1974-1976, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.1974-1976.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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