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Antimicrobial Agents and Chemotherapy, June 2002, p. 1993-1995, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.1993-1995.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Lack of Pharmacokinetic Interaction between the Oral Anti-Influenza Prodrug Oseltamivir and Aspirin

Charles Oo,1* Joanne Barrett,2 Albert Dorr,1 Baolian Liu,1 and Penelope Ward3

F. Hoffman-La Roche, Nutley, New Jersey,1 Roche Global Development, Welwyn,,2 GlaxoSmithKline, Brentford, Middlesex, United Kingdom3

Received 15 October 2001/ Returned for modification 4 January 2002/ Accepted 11 March 2002

Twelve volunteers completed a two-sequence, three-way crossover study of a single 900-mg aspirin dose and multiple doses of 75 mg of oseltamivir in the absence and presence of 900 mg of aspirin. The plasma and urine results demonstrated no pharmacokinetic interaction between oseltamivir and aspirin.

* Corresponding author. Mailing address: Hoffmann-La Roche, Inc., Dept. of Clinical Pharmacology, 340 Kingsland St., Nutley, NJ 07110. Phone: (973) 562-2575. Fax: (973) 235-5635. E-mail: charles.oo{at}roche.com.

Antimicrobial Agents and Chemotherapy, June 2002, p. 1993-1995, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.1993-1995.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Shi, D., Yang, J., Yang, D., LeCluyse, E. L., Black, C., You, L., Akhlaghi, F., Yan, B. (2007). Response to Comments on "Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel". J. Pharmacol. Exp. Ther. 322: 424-425 [Full Text]  


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