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Antimicrobial Agents and Chemotherapy, June 2002, p. 1996-1999, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.1996-1999.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Impact of N-Chlorotaurine on Viability and Production of Secreted Aspartyl Proteinases of Candida spp.

Markus Nagl,1* Andreas Gruber,1 Anita Fuchs,1 Claudia P. Lell,1 Eva-Maria Lemberger,1 Margarete Borg-von Zepelin,2 and Reinhard Würzner1

Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, Innsbruck, Austria,1 Institute of Bacteriology, University Clinics of Göttingen, Göttingen, Germany2

Received 18 July 2001/ Returned for modification 8 October 2001/ Accepted 8 March 2002

N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.

* Corresponding author. Mailing address: Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, Fritz Pregl-Str. 3, A-6010 Innsbruck, Austria. Phone: 43 512 507-3430. Fax: 43 512 507-2870. E-mail: m.nagl{at}uibk.ac.at.

Antimicrobial Agents and Chemotherapy, June 2002, p. 1996-1999, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.1996-1999.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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