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Antimicrobial Agents and Chemotherapy, June 2002, p. 2004-2006, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2004-2006.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Chromosome-Encoded Class D ß-Lactamase OXA-23 in Proteus mirabilis

R. Bonnet,1* H. Marchandin,2 C. Chanal,1 D. Sirot,1 R. Labia,3 C. De Champs,1 E. Jumas-Bilak,4 and J. Sirot1

Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex,1 Laboratoire de Bactériologie, Hôpital Arnaud de Villeneuve, 34295 Montpellier Cedex 5,2 UMR 175, CNRS-MNHN, 29000 Quimper,3 Laboratoire de Bactériologie, Faculté de Pharmacie, 34093 Montpellier Cedex 5, France4

Received 23 July 2001/ Returned for modification 18 November 2001/ Accepted 21 March 2002

Ten nonrepetitive Proteus mirabilis isolates, which were collected over 4 years (1996 to 1999) at the teaching hospital of Clermont-Ferrand, France, produced class D carbapenemase OXA-23. MICs of imipenem were 0.25 to 0.5 µg/ml for these clinical isolates. Molecular typing revealed that the 10 P. mirabilis isolates originated from the same clonal strain. Hybridization of I-CeuI-generated chromosome fragments with a blaOXA-23 probe showed that the gene was chromosome encoded in the P. mirabilis strain.

* Corresponding author. Mailing address: Faculté de Médecine Service de Bactériologie-Virologie, 28, Place Henri Dunant, 63 001 Clermont-Ferrand Cedex, France. Phone: 33 0 4 73 17 8159. Fax: 33 0 4 73 27 74 94. E-mail: Richard.Bonnet{at}u-clermont1.fr.

Antimicrobial Agents and Chemotherapy, June 2002, p. 2004-2006, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2004-2006.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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