This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bonnet, R. Articles by Sirot, J. Search for Related Content PubMed PubMed Citation Articles by Bonnet, R. Articles by Sirot, J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, June 2002, p. 2004-2006, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2004-2006.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Chromosome-Encoded Class D ß-Lactamase OXA-23 in Proteus mirabilis

Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex,¹ Laboratoire de Bactériologie, Hôpital Arnaud de Villeneuve, 34295 Montpellier Cedex 5,² UMR 175, CNRS-MNHN, 29000 Quimper,³ Laboratoire de Bactériologie, Faculté de Pharmacie, 34093 Montpellier Cedex 5, France⁴

Received 23 July 2001/ Returned for modification 18 November 2001/ Accepted 21 March 2002

Ten nonrepetitive Proteus mirabilis isolates, which were collected over 4 years (1996 to 1999) at the teaching hospital of Clermont-Ferrand, France, produced class D carbapenemase OXA-23. MICs of imipenem were 0.25 to 0.5 µg/ml for these clinical isolates. Molecular typing revealed that the 10 P. mirabilis isolates originated from the same clonal strain. Hybridization of I-CeuI-generated chromosome fragments with a bla_OXA-23 probe showed that the gene was chromosome encoded in the P. mirabilis strain.

This article has been cited by other articles:

• Tibbetts, R., Frye, J. G., Marschall, J., Warren, D., Dunne, W. (2008). Detection of KPC-2 in a Clinical Isolate of Proteus mirabilis and First Reported Description of Carbapenemase Resistance Caused by a KPC {beta}-Lactamase in P. mirabilis. J. Clin. Microbiol. 46: 3080-3083 [Abstract] [Full Text]  
• Villegas, M. V., Kattan, J. N., Correa, A., Lolans, K., Guzman, A. M., Woodford, N., Livermore, D., Quinn, J. P., and the Colombian Nosocomial Bacterial Resistance, (2007). Dissemination of Acinetobacter baumannii Clones with OXA-23 Carbapenemase in Colombian Hospitals. Antimicrob. Agents Chemother. 51: 2001-2004 [Abstract] [Full Text]  
• Corvec, S., Poirel, L., Naas, T., Drugeon, H., Nordmann, P. (2007). Genetics and Expression of the Carbapenem-Hydrolyzing Oxacillinase Gene blaOXA-23 in Acinetobacter baumannii. Antimicrob. Agents Chemother. 51: 1530-1533 [Abstract] [Full Text]  
• Hujer, K. M., Hujer, A. M., Hulten, E. A., Bajaksouzian, S., Adams, J. M., Donskey, C. J., Ecker, D. J., Massire, C., Eshoo, M. W., Sampath, R., Thomson, J. M., Rather, P. N., Craft, D. W., Fishbain, J. T., Ewell, A. J., Jacobs, M. R., Paterson, D. L., Bonomo, R. A. (2006). Analysis of Antibiotic Resistance Genes in Multidrug-Resistant Acinetobacter sp. Isolates from Military and Civilian Patients Treated at the Walter Reed Army Medical Center. Antimicrob. Agents Chemother. 50: 4114-4123 [Abstract] [Full Text]  
• Walther-Rasmussen, J., Hoiby, N. (2006). OXA-type carbapenemases. J Antimicrob Chemother 57: 373-383 [Abstract] [Full Text]  
• Brown, S., Amyes, S. (2006). OXA {beta}-lactamases in Acinetobacter: the story so far. J Antimicrob Chemother 57: 1-3 [Abstract] [Full Text]  
• Lavigne, J.-P., Marchandin, H., Bouziges, N., Sotto, A. (2005). First Infection with VanD-Type Glycopeptide-Resistant Enterococcus faecium in Europe. J. Clin. Microbiol. 43: 3512-3515 [Abstract] [Full Text]  
• Jeon, B.-C., Jeong, S. H., Bae, I. K., Kwon, S. B., Lee, K., Young, D., Lee, J. H., Song, J. S., Lee, S. H. (2005). Investigation of a Nosocomial Outbreak of Imipenem-Resistant Acinetobacter baumannii Producing the OXA-23 {beta}-Lactamase in Korea. J. Clin. Microbiol. 43: 2241-2245 [Abstract] [Full Text]  
• Marchandin, H., Jean-Pierre, H., Campos, J., Dubreuil, L., Teyssier, C., Jumas-Bilak, E. (2004). nimE Gene in a Metronidazole-Susceptible Veillonella sp. Strain. Antimicrob. Agents Chemother. 48: 3207-3208 [Full Text]  
• Heritier, C., Poirel, L., Nordmann, P. (2004). Genetic and Biochemical Characterization of a Chromosome-Encoded Carbapenem-Hydrolyzing Ambler Class D {beta}-Lactamase from Shewanella algae. Antimicrob. Agents Chemother. 48: 1670-1675 [Abstract] [Full Text]  
• Poirel, L., Heritier, C., Tolun, V., Nordmann, P. (2004). Emergence of Oxacillinase-Mediated Resistance to Imipenem in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 48: 15-22 [Abstract] [Full Text]  
• Poirel, L., Heritier, C., Nordmann, P. (2004). Chromosome-Encoded Ambler Class D {beta}-Lactamase of Shewanella oneidensis as a Progenitor of Carbapenem-Hydrolyzing Oxacillinase. Antimicrob. Agents Chemother. 48: 348-351 [Abstract] [Full Text]  
• Dalla-Costa, L. M., Coelho, J. M., Souza, H. A. P. H. M., Castro, M. E. S., Stier, C. J. N., Bragagnolo, K. L., Rea-Neto, A., Penteado-Filho, S. R., Livermore, D. M., Woodford, N. (2003). Outbreak of Carbapenem-Resistant Acinetobacter baumannii Producing the OXA-23 Enzyme in Curitiba, Brazil. J. Clin. Microbiol. 41: 3403-3406 [Abstract] [Full Text]  
• Heritier, C., Poirel, L., Aubert, D., Nordmann, P. (2003). Genetic and Functional Analysis of the Chromosome-Encoded Carbapenem-Hydrolyzing Oxacillinase OXA-40 of Acinetobacter baumannii. Antimicrob. Agents Chemother. 47: 268-273 [Abstract] [Full Text]