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Antimicrobial Agents and Chemotherapy, June 2002, p. 2010-2013, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2010-2013.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Effects of Synthetic Siderophores on Proliferation of Plasmodium falciparum in Infected Human Erythrocytes

Andrea Rotheneder,1 Gernot Fritsche,1 Lothar Heinisch,2 Ute Möllmann,2 Susanne Heggemann,2 Clara Larcher,3 and Günter Weiss1*

Department of Internal Medicine, University Hospital of Innsbruck,1 Institute for Hygiene and Social Medicine, University of Innsbruck, A-6020 Innsbruck, Austria,3 Hans-Knöll Institute for Natural Product Research, Jena, Germany2

Received 3 December 2001/ Returned for modification 4 January 2002/ Accepted 6 March 2002

Because iron is essential for Plasmodium falciparum, we investigated the in vitro potential of various synthetic siderophores to kill P. falciparum in infected human erythrocytes. The substances with the most promising profile, i.e., low 50% lethal doses for plasmodia and minimum toxicity towards mammalian cells, were siderophores with an acylated monocatecholate or a triscatecholate as substituent.

* Corresponding author. Mailing address: Department of Internal Medicine, University Hospital, Anichstr. 35, A-6020 Innsbruck, Austria. Phone: 43-512-504-3255. Fax: 43-512-504-3293. E-mail: guenter.weiss{at}uibk.ac.at.

Antimicrobial Agents and Chemotherapy, June 2002, p. 2010-2013, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2010-2013.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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