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Antimicrobial Agents and Chemotherapy, June 2002, p. 2021-2023, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2021-2023.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Helicobacter pylori Primary Resistance to Metronidazole and Clarithromycin in Brazil

Paula Prazeres Magalhães,1,2,3 Dulciene Maria de Magalhães Queiroz,1* Daniela Vale Campos Barbosa,1 Gifone Aguiar Rocha,1 Edilberto Nogueira Mendes,1 Adriana Santos,1 Paulo Renato Valle Corrêa,1 Andreia Maria Camargos Rocha,1 Lúcia Martins Teixeira,2 and Celso Affonso de Oliveira1

Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte,1 Faculdade de Fisioterapia, Universidade de Itaúna, Itaúna, Minas Gerais,3 Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil2

Received 12 September 2001/ Returned for modification 8 January 2002/ Accepted 19 February 2002

Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, 18 of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed over time.

* Corresponding author. Mailing address: Laboratory of Research in Bacteriology, Faculdade de Medicina, UFMG, Av. Alfredo Balena, 190, Sala 4026, 30130-100, Belo Horizonte, Brazil. Phone and fax: 55 31 3274 2767. E-mail: dqueiroz{at}medicina.ufmg.br.

Antimicrobial Agents and Chemotherapy, June 2002, p. 2021-2023, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2021-2023.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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