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Antimicrobial Agents and Chemotherapy, June 2002, p. 2029-2031, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2029-2031.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Pentamidine, Pyrimethamine, Trimethoprim, and Sulfonamides against Aspergillus Species

Javier Afeltra,1 Jacques F. G. M. Meis,2 Roxana G. Vitale,1 Johan W. Mouton,2 Paul E. Verweij,1* and Eurofung Network{dagger}

Department of Medical Microbiology, University Medical Center Nijmegen,,1 Department of Medical Microbiology and Infectious Diseases, Canisius Wilhemina Hospital, Nijmegen, The Netherlands2

Received 29 November 2001/ Returned for modification 4 January 2002/ Accepted 11 March 2002

The susceptibilities of 70 strains of Aspergillus species were tested against seven different sulfa drugs and pentamidine by a microdilution method with RPMI 1640 and yeast nitrogen base media. Sulfamethoxazole, sulfadiazine, and pentamidine were active in vitro. The MICs obtained with RPMI 1640 were significantly higher than those with yeast nitrogen base. More studies are needed to further elucidate the action of these drugs.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3614356. Fax: 31-24-3540216. E-mail: p.verweij{at}mmb.azn.nl.

{dagger} Participants are listed in the Appendix.

Antimicrobial Agents and Chemotherapy, June 2002, p. 2029-2031, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2029-2031.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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