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Antimicrobial Agents and Chemotherapy, June 2002, p. 2032-2034, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2032-2034.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Efficacy of ß-Lactams for Treating Experimentally Induced Pneumonia Due to a Carbapenem-Hydrolyzing Metallo-ß-Lactamase-Producing Strain of Pseudomonas aeruginosa

Samuel Bellais,1 Olivier Mimoz,2,3 Sophie Léotard,1 Anne Jacolot,3 Olivier Petitjean,3 and Patrice Nordmann1*

Service de Bactériologie-Virologie-Hygiène, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine de Paris-Sud, 94275 Le Kremlin-Bicêtre,1 Département d'Anesthésie et de Réanimation Chirurgicale, Centre Hospitalo- Universitaire la Milétrie, 86021 Poitiers,2 Crépit 93, Centre de Recherche en Pathologie Infectieuse et Tropicale, Faculté de Médecine de Paris-Nord, 93009 Bobigny, France3

Received 14 August 2001/ Returned for modification 6 January 2002/ Accepted 22 March 2002

A rat pneumonia model was established with a Pseudomonas aeruginosa strain that produced the plasmid-encoded metallocarbapenemase VIM-2. A significant decrease in lung bacterial titers was observed when imipenem, cefepime, ceftazidime, and piperacillin-tazobactam were given at the highest doses recommended for humans, despite their high MICs. Aztreonam at high doses produced a similar decrease in bacterial titers.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie-Hygiène, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, June 2002, p. 2032-2034, Vol. 46, No. 6
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.6.2032-2034.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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