This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Diallo, K.
Right arrow Articles by Götte, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diallo, K.
Right arrow Articles by Götte, M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, July 2002, p. 2254-2256, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2254-2256.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Pressure of Zidovudine Accelerates the Reversion of Lamivudine Resistance-Conferring M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1

Karidia Diallo,1,2 Maureen Oliveira,1 Daniela Moisi,1 Bluma Brenner,1 Mark A. Wainberg,1,2,3 and Matthias Götte1,2,3*

McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital,1 Departments of Microbiology and Immunology,2 Experimental Medicine, McGill University, Montreal, H3T 1E2 Quebec, Canada3

Received 6 November 2001/ Returned for modification 24 January 2002/ Accepted 8 April 2002

We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the resistance-conferring M184V mutation. These data suggest that the presence of ZDV amplifies differences in replication capacity between wild-type HIV-1 and the mutant variant.

* Corresponding author. Mailing address: McGill AIDS Centre, Lady Davis Institute-Jewish General Hospital, 3755 Chemin Côte-Ste-Catherine, Montreal, Quebec H3T 1E2, Canada. Phone: (514) 340-8222, x3299. Fax: (514) 340-7537. E-mail: mgoette{at}ldi.jgh.mcgill.ca.

Antimicrobial Agents and Chemotherapy, July 2002, p. 2254-2256, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2254-2256.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Murry, J. P., Higgins, J., Matthews, T. B., Huang, V. Y., Van Rompay, K. K. A., Pedersen, N. C., North, T. W. (2002). Reversion of the M184V Mutation in Simian Immunodeficiency Virus Reverse Transcriptase Is Selected by Tenofovir, Even in the Presence of Lamivudine. J. Virol. 77: 1120-1130 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»