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Antimicrobial Agents and Chemotherapy, July 2002, p. 2254-2256, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2254-2256.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Pressure of Zidovudine Accelerates the Reversion of Lamivudine Resistance-Conferring M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1

McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital,¹ Departments of Microbiology and Immunology,² Experimental Medicine, McGill University, Montreal, H3T 1E2 Quebec, Canada³

Received 6 November 2001/ Returned for modification 24 January 2002/ Accepted 8 April 2002

We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the resistance-conferring M184V mutation. These data suggest that the presence of ZDV amplifies differences in replication capacity between wild-type HIV-1 and the mutant variant.

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• Murry, J. P., Higgins, J., Matthews, T. B., Huang, V. Y., Van Rompay, K. K. A., Pedersen, N. C., North, T. W. (2002). Reversion of the M184V Mutation in Simian Immunodeficiency Virus Reverse Transcriptase Is Selected by Tenofovir, Even in the Presence of Lamivudine. J. Virol. 77: 1120-1130 [Abstract] [Full Text]