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Antimicrobial Agents and Chemotherapy, July 2002, p. 2262-2265, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2262-2265.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Novel Plasmid-Encoded Class C ß-Lactamase (MOX-2) in Klebsiella pneumoniae from Greece

Laurent Raskine,1* Isabelle Borrel,1 Guilène Barnaud,1 Sophie Boyer,1,{dagger} Béatrice Hanau-Berçot,1 Jérome Gravisse,1 Roger Labia,2 Guillaume Arlet,3 and Marie-José Sanson-Le-Pors1

Service de Bacteriologie-Virologie, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 75475 Paris Cedex 10,1 Centre National de la Recherche Scientifique, Unité FRE 2125, 29000 Quimper,2 Service de Bactériologie, Hôpital Tenon, AP-HP, 75970 Paris Cedex 20, France3

Received 15 October 2001/ Returned for modification 12 January 2002/ Accepted 7 April 2002

Klebsiella pneumoniae KOL, a clinical strain resistant to various ß-lactams, was isolated from the stools of a patient from Greece. This strain harbored a new pI 9.1 plasmid-mediated AmpC ß-lactamase with unusually high levels of hydrolytic activity for cefoxitin and cefotetan that we named MOX-2. Sequencing of blaMOX-2 revealed 93.2, 92.9, 92.7, and 73.1% identities with the deduced amino acid sequences of CMY-8, MOX-1, CMY-1, and the AmpC ß-lactamase of Aeromonas sobria, respectively.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital Lariboisière, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. Phone: 33 1 49 95 85 39. Fax: 33 1 49 95 85 37. E-mail: laurent.raskine{at}lrb.ap-hop-paris.fr.

{dagger} Present address: Laboratoire de la Polyclinique d'Aubervilliers, Hôpital Européen de Paris, 93300 Aubervilliers, France.

Antimicrobial Agents and Chemotherapy, July 2002, p. 2262-2265, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2262-2265.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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