This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhao, W.-H.
Right arrow Articles by Shimamura, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhao, W.-H.
Right arrow Articles by Shimamura, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, July 2002, p. 2266-2268, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2266-2268.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Inhibition of Penicillinase by Epigallocatechin Gallate Resulting in Restoration of Antibacterial Activity of Penicillin against Penicillinase-Producing Staphylococcus aureus

Wei-Hua Zhao,1* Zhi-Qing Hu,1 Yukihiko Hara,2 and Tadakatsu Shimamura1

Department of Microbiology and Immunology, Showa University School of Medicine,1 Tokyo Food Techno Co., Ltd., Tokyo, Japan2

Received 11 January 2002/ Returned for modification 11 March 2002/ Accepted 10 April 2002

The combination of epigallocatechin gallate (EGCg, a main constituent of tea catechins) with penicillin showed synergism against 21 clinical isolates of penicillinase-producing Staphylococcus aureus. Besides binding directly to peptidoglycan, the inhibition of penicillinase activity by EGCg is responsible for the synergism. EGCg inhibited the penicillinase activity in a dose-dependent fashion, with a 50% inhibitory concentration of 10 µg/ml.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. Phone: 81-3-3784-8131. Fax: 81-3-3784-3069. E-mail: whzhao{at}med.showa-u.ac.jp.

Antimicrobial Agents and Chemotherapy, July 2002, p. 2266-2268, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2266-2268.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zhao, W.-H., Hu, Z.-Q., Shimamura, T. (2008). Potency of IMP-10 metallo-{beta}-lactamase in hydrolysing various antipseudomonal {beta}-lactams. J Med Microbiol 57: 974-979 [Abstract] [Full Text]  
  • Blanco, A. R., Sudano-Roccaro, A., Spoto, G. C., Nostro, A., Rusciano, D. (2005). Epigallocatechin Gallate Inhibits Biofilm Formation by Ocular Staphylococcal Isolates. Antimicrob. Agents Chemother. 49: 4339-4343 [Abstract] [Full Text]  
  • Sudano Roccaro, A., Blanco, A. R., Giuliano, F., Rusciano, D., Enea, V. (2004). Epigallocatechin-Gallate Enhances the Activity of Tetracycline in Staphylococci by Inhibiting Its Efflux from Bacterial Cells. Antimicrob. Agents Chemother. 48: 1968-1973 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»