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Antimicrobial Agents and Chemotherapy, July 2002, p. 2266-2268, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2266-2268.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Inhibition of Penicillinase by Epigallocatechin Gallate Resulting in Restoration of Antibacterial Activity of Penicillin against Penicillinase-Producing Staphylococcus aureus

Wei-Hua Zhao,1* Zhi-Qing Hu,1 Yukihiko Hara,2 and Tadakatsu Shimamura1

Department of Microbiology and Immunology, Showa University School of Medicine,1 Tokyo Food Techno Co., Ltd., Tokyo, Japan2

Received 11 January 2002/ Returned for modification 11 March 2002/ Accepted 10 April 2002

The combination of epigallocatechin gallate (EGCg, a main constituent of tea catechins) with penicillin showed synergism against 21 clinical isolates of penicillinase-producing Staphylococcus aureus. Besides binding directly to peptidoglycan, the inhibition of penicillinase activity by EGCg is responsible for the synergism. EGCg inhibited the penicillinase activity in a dose-dependent fashion, with a 50% inhibitory concentration of 10 µg/ml.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. Phone: 81-3-3784-8131. Fax: 81-3-3784-3069. E-mail: whzhao{at}med.showa-u.ac.jp.

Antimicrobial Agents and Chemotherapy, July 2002, p. 2266-2268, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2266-2268.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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