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Antimicrobial Agents and Chemotherapy, July 2002, p. 2273-2275, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2273-2275.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Efficacy of Liposomal Amphotericin B in Treatment of Systemic Murine Fusariosis

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut and Institut d'Estudis Avançats,¹ Laboratori de Microbiologia, Hospital Universitari de Sant Joan de Reus, Universitat Rovira i Virgili, 43201 Reus, Spain²

Received 28 January 2002/ Returned for modification 6 March 2002/ Accepted 12 April 2002

We have compared the activities of liposomal amphotericin B (LAMB) at 3, 5, 10, and 20 mg/kg/day and amphotericin B deoxycholate (AMB) at 1.5 and 2.5 mg/kg/day in a murine systemic infection by Fusarium verticillioides. Survival was improved by all treatments except AMB at 1.5 mg/kg/day. The tissue burden in liver was reduced by LAMB at all dosages and by AMB at 2.5 mg/kg/day. The two highest dosages of LAMB showed significant reductions in the spleen.

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