AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Solbrig, M. V.
Right arrow Articles by Lipkin, W. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Solbrig, M. V.
Right arrow Articles by Lipkin, W. I.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, July 2002, p. 2287-2291, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2287-2291.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Neuroprotection and Reduced Proliferation of Microglia in Ribavirin-Treated Bornavirus-Infected Rats

Marylou V. Solbrig,1 Robert Schlaberg,1,2 Thomas Briese,1 Nigel Horscroft,1,3 and W. Ian Lipkin1*

Emerging Diseases Laboratory, University of California—Irvine, Irvine,1 ICN Pharmaceuticals, Costa Mesa, California,3 University of Würzburg, Würzburg, Germany2

Received 2 July 2001/ Returned for modification 3 October 2001/ Accepted 21 March 2002

In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1ß (IL-1ß), IL-10, and gamma interferon in the brain. Intracerebral ribavirin may reduce morbidity through effects on microglia cell proliferation.

* Corresponding author. Mailing address: Mailman School of Public Health, Columbia University, New York, NY 10032. Phone: (212) 851-5393. Fax: (212) 851-5395. E-mail: wil2001{at}columbia.edu.

Antimicrobial Agents and Chemotherapy, July 2002, p. 2287-2291, Vol. 46, No. 7
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.7.2287-2291.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2002 by the American Society for Microbiology. All rights reserved.